Congenital diarrhea with intestinal inflammation and epithelial immaturity

M. E. Kanof, Naomi E Rance, S. R. Hamilton, G. D. Luk, A. M. Lake

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report an interesting case of congenital inflammatory bowel disease and intestinal epithelial immaturity that presented as secretory diarrhea. No infectious, metabolic, or anatomical basis for these findings was identified. As differentiated from previous reports of neonatal enteropathies, this infant demonstrated involvement of both the small and large intestine with histopathologic findings of acute and chronic inflammation, extensive submucosal fibrosis, and 'flat' small intestine mucosa. In addition, this patient had a polyamine deficiency (a primary or secondary phenomenon), which may have contributed to delayed epithelial maturation. These findings suggest that the inflammatory bowel disease and altered epithelial maturation contributed to a fatal intractable diarrhea.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume6
Issue number1
StatePublished - 1987
Externally publishedYes

Fingerprint

inflammatory bowel disease
Inflammatory Bowel Diseases
Small Intestine
small intestine
Diarrhea
diarrhea
inflammation
Inflammation
Large Intestine
Polyamines
large intestine
polyamines
digestive system diseases
fibrosis
mucosa
Mucous Membrane
Fibrosis
case studies

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Congenital diarrhea with intestinal inflammation and epithelial immaturity. / Kanof, M. E.; Rance, Naomi E; Hamilton, S. R.; Luk, G. D.; Lake, A. M.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 6, No. 1, 1987, p. 141-146.

Research output: Contribution to journalArticle

Kanof, M. E. ; Rance, Naomi E ; Hamilton, S. R. ; Luk, G. D. ; Lake, A. M. / Congenital diarrhea with intestinal inflammation and epithelial immaturity. In: Journal of Pediatric Gastroenterology and Nutrition. 1987 ; Vol. 6, No. 1. pp. 141-146.
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