Abstract
The association of congenital heart block with maternal connective tissue disease and autoimmunity has been recently reported. Two cases of heart block were diagnosed in utero at 23 and 24 weeks' gestation. Both mothers had extensive workups for connective tissue disease that were negative. Two-dimensional and Doppler echocardiography were performed in utero and both infants had left atrial isomerism, atrioventricular canal defects, and severe hydrops in addition to heart block. Review of the recent literature identifies a subset of congenital heart block in which the mothers have no evidence for connective tissue disease, and the fetus or neonate has complex cardiac malformations and hydrops. The common features in these babies are atrioventricular canal defects and isomerism. No reports of congenital heart disease among the children of mothers with connective tissue disease fit this description. Our recent experience and literature review emphasize the previously known association between congenital heart block and congenital heart disease. This association is especially important in light of the poor prognosis for this group of fetuses and neonates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-253 |
| Number of pages | 6 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 157 |
| Issue number | 2 |
| State | Published - Aug 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Congenital heart block and cardiac anomalies in the absence of maternal connective tissue disease. / Shenker, L.; Reed, Kathryn L; Anderson, C. F.; Marx, G. R.; Sobonya, Richard E; Graham, A. R.
In: American Journal of Obstetrics and Gynecology, Vol. 157, No. 2, 08.1987, p. 248-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Congenital heart block and cardiac anomalies in the absence of maternal connective tissue disease.
AU - Shenker, L.
AU - Reed, Kathryn L
AU - Anderson, C. F.
AU - Marx, G. R.
AU - Sobonya, Richard E
AU - Graham, A. R.
PY - 1987/8
Y1 - 1987/8
N2 - The association of congenital heart block with maternal connective tissue disease and autoimmunity has been recently reported. Two cases of heart block were diagnosed in utero at 23 and 24 weeks' gestation. Both mothers had extensive workups for connective tissue disease that were negative. Two-dimensional and Doppler echocardiography were performed in utero and both infants had left atrial isomerism, atrioventricular canal defects, and severe hydrops in addition to heart block. Review of the recent literature identifies a subset of congenital heart block in which the mothers have no evidence for connective tissue disease, and the fetus or neonate has complex cardiac malformations and hydrops. The common features in these babies are atrioventricular canal defects and isomerism. No reports of congenital heart disease among the children of mothers with connective tissue disease fit this description. Our recent experience and literature review emphasize the previously known association between congenital heart block and congenital heart disease. This association is especially important in light of the poor prognosis for this group of fetuses and neonates.
AB - The association of congenital heart block with maternal connective tissue disease and autoimmunity has been recently reported. Two cases of heart block were diagnosed in utero at 23 and 24 weeks' gestation. Both mothers had extensive workups for connective tissue disease that were negative. Two-dimensional and Doppler echocardiography were performed in utero and both infants had left atrial isomerism, atrioventricular canal defects, and severe hydrops in addition to heart block. Review of the recent literature identifies a subset of congenital heart block in which the mothers have no evidence for connective tissue disease, and the fetus or neonate has complex cardiac malformations and hydrops. The common features in these babies are atrioventricular canal defects and isomerism. No reports of congenital heart disease among the children of mothers with connective tissue disease fit this description. Our recent experience and literature review emphasize the previously known association between congenital heart block and congenital heart disease. This association is especially important in light of the poor prognosis for this group of fetuses and neonates.
UR - http://www.scopus.com/inward/record.url?scp=0023393337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023393337&partnerID=8YFLogxK
M3 - Article
C2 - 3618667
AN - SCOPUS:0023393337
VL - 157
SP - 248
EP - 253
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -