Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.

Translated title of the contribution: Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide

N. I. Larionova, I. P. Gladysheva, I. N. Topchieva, N. F. Kazanskaia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.

Translated title of the contributionConjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide
Original languageRussian
Pages (from-to)1658-1664
Number of pages7
JournalBiokhimiya
Volume58
Issue number10
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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