Connexin mimetic peptides

Specific inhibitors of gap-junctional intercellular communication

W. H. Evans, Scott A Boitano

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Intercellular co-operation is a fundamental and widespread feature in tissues and organs. An important mechanism ensuring multicellular homoeostasis involves signalling between cells via gap junctions that directly connect the cytosolic contents of adjacent cells. Cell proliferation and intercellular communication across gap junctions are closely linked, and a number of pathologies in which communication is disrupted are known where connexins, the gap-junctional proteins, are modified. The proteins of gap junctions thus emerge as therapeutic targets inviting the development and exploitation of chemical tools and drugs that specifically influence intercellular communication. Connexin mimetic peptides that correspond to short specific sequences in the two extracellular loops of connexins are a class of benign, specific and reversible inhibitors of gap-junctional communication that have been studied recently in a broad range of cells, tissues and organs. This review summarizes the properties and uses of these short synthetic peptides, and compares their probable mechanism of action with those of a wide range of other less specific traditional gap-junction inhibitors.

Original languageEnglish (US)
Pages (from-to)606-612
Number of pages7
JournalBiochemical Society Transactions
Volume29
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Connexins
Gap Junctions
Peptides
Communication
Tissue
Cell signaling
Cell proliferation
Pathology
Homeostasis
Cell Proliferation
Pharmaceutical Preparations
Proteins
Therapeutics

Keywords

  • Cell interactions
  • Cell signalling
  • Gap junction inhibitors

ASJC Scopus subject areas

  • Biochemistry

Cite this

Connexin mimetic peptides : Specific inhibitors of gap-junctional intercellular communication. / Evans, W. H.; Boitano, Scott A.

In: Biochemical Society Transactions, Vol. 29, No. 4, 2001, p. 606-612.

Research output: Contribution to journalArticle

@article{a0ea26b5b0af4d4aa7f6f02f36341658,
title = "Connexin mimetic peptides: Specific inhibitors of gap-junctional intercellular communication",
abstract = "Intercellular co-operation is a fundamental and widespread feature in tissues and organs. An important mechanism ensuring multicellular homoeostasis involves signalling between cells via gap junctions that directly connect the cytosolic contents of adjacent cells. Cell proliferation and intercellular communication across gap junctions are closely linked, and a number of pathologies in which communication is disrupted are known where connexins, the gap-junctional proteins, are modified. The proteins of gap junctions thus emerge as therapeutic targets inviting the development and exploitation of chemical tools and drugs that specifically influence intercellular communication. Connexin mimetic peptides that correspond to short specific sequences in the two extracellular loops of connexins are a class of benign, specific and reversible inhibitors of gap-junctional communication that have been studied recently in a broad range of cells, tissues and organs. This review summarizes the properties and uses of these short synthetic peptides, and compares their probable mechanism of action with those of a wide range of other less specific traditional gap-junction inhibitors.",
keywords = "Cell interactions, Cell signalling, Gap junction inhibitors",
author = "Evans, {W. H.} and Boitano, {Scott A}",
year = "2001",
doi = "10.1042/BST0290606",
language = "English (US)",
volume = "29",
pages = "606--612",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "4",

}

TY - JOUR

T1 - Connexin mimetic peptides

T2 - Specific inhibitors of gap-junctional intercellular communication

AU - Evans, W. H.

AU - Boitano, Scott A

PY - 2001

Y1 - 2001

N2 - Intercellular co-operation is a fundamental and widespread feature in tissues and organs. An important mechanism ensuring multicellular homoeostasis involves signalling between cells via gap junctions that directly connect the cytosolic contents of adjacent cells. Cell proliferation and intercellular communication across gap junctions are closely linked, and a number of pathologies in which communication is disrupted are known where connexins, the gap-junctional proteins, are modified. The proteins of gap junctions thus emerge as therapeutic targets inviting the development and exploitation of chemical tools and drugs that specifically influence intercellular communication. Connexin mimetic peptides that correspond to short specific sequences in the two extracellular loops of connexins are a class of benign, specific and reversible inhibitors of gap-junctional communication that have been studied recently in a broad range of cells, tissues and organs. This review summarizes the properties and uses of these short synthetic peptides, and compares their probable mechanism of action with those of a wide range of other less specific traditional gap-junction inhibitors.

AB - Intercellular co-operation is a fundamental and widespread feature in tissues and organs. An important mechanism ensuring multicellular homoeostasis involves signalling between cells via gap junctions that directly connect the cytosolic contents of adjacent cells. Cell proliferation and intercellular communication across gap junctions are closely linked, and a number of pathologies in which communication is disrupted are known where connexins, the gap-junctional proteins, are modified. The proteins of gap junctions thus emerge as therapeutic targets inviting the development and exploitation of chemical tools and drugs that specifically influence intercellular communication. Connexin mimetic peptides that correspond to short specific sequences in the two extracellular loops of connexins are a class of benign, specific and reversible inhibitors of gap-junctional communication that have been studied recently in a broad range of cells, tissues and organs. This review summarizes the properties and uses of these short synthetic peptides, and compares their probable mechanism of action with those of a wide range of other less specific traditional gap-junction inhibitors.

KW - Cell interactions

KW - Cell signalling

KW - Gap junction inhibitors

UR - http://www.scopus.com/inward/record.url?scp=0034859572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034859572&partnerID=8YFLogxK

U2 - 10.1042/BST0290606

DO - 10.1042/BST0290606

M3 - Article

VL - 29

SP - 606

EP - 612

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 4

ER -