Conservation and Convergence of Immune Signaling Pathways With Mitochondrial Regulation in Vector Arthropod Physiology

Shirley Luckhart, Michael A Riehle

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The blood meal provides more than simple nutrition to the hematophagous arthropod. It provides a wealth of signaling information through a variety of components present in the blood meal. These signaling factors in turn activate highly conserved signaling cascades at the blood meal-interface between the blood and gut, allowing the information to be processed and utilized by the arthropod to regulate a wide range of physiological processes including innate immunity, reproduction, and life span. Mounting evidence points to mitochondrial activity, mitophagy, and biogenesis as key gatekeepers between information from the blood meal and downstream physiological effects. In this chapter we frame the history of insect pathogen interactions and the challenges blood-feeding insects face, the importance of the blood meal interface, and the signaling cascades that transduce the blood meal information, and finally the role mitochondrial dynamics plays in interpreting blood meal information and in regulating broad physiologies critical for the transmission of pathogens.

Original languageEnglish (US)
Title of host publicationVector Microbiome and Innate Immunity of Arthropods
PublisherElsevier Inc.
Pages15-33
Number of pages19
Volume1
ISBN (Electronic)9780128092378
ISBN (Print)9780128053508
DOIs
StatePublished - Apr 27 2017

Fingerprint

Arthropod Vectors
blood meal
arthropods
physiology
Meals
Arthropods
hematophagous arthropods
Insects
entomopathogens
Mitochondrial Degradation
blood
Mitochondrial Dynamics
Physiological Phenomena
Infectious Disease Transmission
digestive system
Innate Immunity
Reproduction
nutrition
history
insects

Keywords

  • Arthropod vector
  • Biogenesis
  • Blood-feeding interface
  • Immunity
  • Insulin signaling
  • Life span
  • Mitochondria
  • Mitogen-activated protein kinase
  • Mitophagy
  • Transforming growth factor?

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Conservation and Convergence of Immune Signaling Pathways With Mitochondrial Regulation in Vector Arthropod Physiology. / Luckhart, Shirley; Riehle, Michael A.

Vector Microbiome and Innate Immunity of Arthropods. Vol. 1 Elsevier Inc., 2017. p. 15-33.

Research output: Chapter in Book/Report/Conference proceedingChapter

Luckhart, Shirley ; Riehle, Michael A. / Conservation and Convergence of Immune Signaling Pathways With Mitochondrial Regulation in Vector Arthropod Physiology. Vector Microbiome and Innate Immunity of Arthropods. Vol. 1 Elsevier Inc., 2017. pp. 15-33
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