Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum

Lisa M Nagy, Seen Carroll

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

During embryogenesis, all insects reach a conserved, or phylotypic, stage at which all future segments are present. Different insects, however, arrive at this stage by overtly different pathways. In the long-germ insect Drosophila melanogaster, segmentation of the entire embryo occurs nearly simultaneously and results from the action of a cascade of transcriptional regulatory factors that operate in the acellular environment of the syncytial blastoderm. In short-germ insects, segmentation occurs in an anterior-to-posterior sequence, within a cellular environment, and might then be dependent on intercellular signalling. To compare the molecular mechanisms of segmentation, we have isolated a homologue of the Drosophila wingless gene, a mediator of cell-cell communications, from the short-germ beetle Tribolium castaneum. The principal features of wingless expression patterns in Drosophila are conserved in Tribolium, including its early deployment in rostral and caudal domains in the blastoderm, its segmental iteration in cells immediately anterior to cells expressing the engrailed gene, and its later restriction to a ventral sector of the developing appendages.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalNature
Volume367
Issue number6462
DOIs
StatePublished - Feb 3 1994
Externally publishedYes

Fingerprint

Tribolium
Insects
Embryonic Structures
Blastoderm
Drosophila
Beetles
Drosophila melanogaster
Cell Communication
Genes
Embryonic Development

ASJC Scopus subject areas

  • General

Cite this

Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum. / Nagy, Lisa M; Carroll, Seen.

In: Nature, Vol. 367, No. 6462, 03.02.1994, p. 460-463.

Research output: Contribution to journalArticle

@article{3b46765e7ace41f38ef804178616860a,
title = "Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum",
abstract = "During embryogenesis, all insects reach a conserved, or phylotypic, stage at which all future segments are present. Different insects, however, arrive at this stage by overtly different pathways. In the long-germ insect Drosophila melanogaster, segmentation of the entire embryo occurs nearly simultaneously and results from the action of a cascade of transcriptional regulatory factors that operate in the acellular environment of the syncytial blastoderm. In short-germ insects, segmentation occurs in an anterior-to-posterior sequence, within a cellular environment, and might then be dependent on intercellular signalling. To compare the molecular mechanisms of segmentation, we have isolated a homologue of the Drosophila wingless gene, a mediator of cell-cell communications, from the short-germ beetle Tribolium castaneum. The principal features of wingless expression patterns in Drosophila are conserved in Tribolium, including its early deployment in rostral and caudal domains in the blastoderm, its segmental iteration in cells immediately anterior to cells expressing the engrailed gene, and its later restriction to a ventral sector of the developing appendages.",
author = "Nagy, {Lisa M} and Seen Carroll",
year = "1994",
month = "2",
day = "3",
doi = "10.1038/367460a0",
language = "English (US)",
volume = "367",
pages = "460--463",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6462",

}

TY - JOUR

T1 - Conservation of wingless patterning functions in the short-germ embryos of Tribolium castaneum

AU - Nagy, Lisa M

AU - Carroll, Seen

PY - 1994/2/3

Y1 - 1994/2/3

N2 - During embryogenesis, all insects reach a conserved, or phylotypic, stage at which all future segments are present. Different insects, however, arrive at this stage by overtly different pathways. In the long-germ insect Drosophila melanogaster, segmentation of the entire embryo occurs nearly simultaneously and results from the action of a cascade of transcriptional regulatory factors that operate in the acellular environment of the syncytial blastoderm. In short-germ insects, segmentation occurs in an anterior-to-posterior sequence, within a cellular environment, and might then be dependent on intercellular signalling. To compare the molecular mechanisms of segmentation, we have isolated a homologue of the Drosophila wingless gene, a mediator of cell-cell communications, from the short-germ beetle Tribolium castaneum. The principal features of wingless expression patterns in Drosophila are conserved in Tribolium, including its early deployment in rostral and caudal domains in the blastoderm, its segmental iteration in cells immediately anterior to cells expressing the engrailed gene, and its later restriction to a ventral sector of the developing appendages.

AB - During embryogenesis, all insects reach a conserved, or phylotypic, stage at which all future segments are present. Different insects, however, arrive at this stage by overtly different pathways. In the long-germ insect Drosophila melanogaster, segmentation of the entire embryo occurs nearly simultaneously and results from the action of a cascade of transcriptional regulatory factors that operate in the acellular environment of the syncytial blastoderm. In short-germ insects, segmentation occurs in an anterior-to-posterior sequence, within a cellular environment, and might then be dependent on intercellular signalling. To compare the molecular mechanisms of segmentation, we have isolated a homologue of the Drosophila wingless gene, a mediator of cell-cell communications, from the short-germ beetle Tribolium castaneum. The principal features of wingless expression patterns in Drosophila are conserved in Tribolium, including its early deployment in rostral and caudal domains in the blastoderm, its segmental iteration in cells immediately anterior to cells expressing the engrailed gene, and its later restriction to a ventral sector of the developing appendages.

UR - http://www.scopus.com/inward/record.url?scp=0028085098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028085098&partnerID=8YFLogxK

U2 - 10.1038/367460a0

DO - 10.1038/367460a0

M3 - Article

C2 - 8107804

AN - SCOPUS:0028085098

VL - 367

SP - 460

EP - 463

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6462

ER -