Constitutive activity at the cannabinoid CB1 receptor and behavioral responses

Katherine E. Hanlon, Todd W Vanderah

Research output: Book/ReportBook

2 Citations (Scopus)

Abstract

The cannabinoid receptor type 1, found mainly on cells of the central and peripheral nervous system, is a major component of the endogenous cannabinoid system. Constitutive and endogenous activity at cannabinoid receptor type 1 regulates a diverse subset of biological processes including appetite, mood, motor function, learning and memory, and pain. The complexity of cannabinoid receptor type 1 activity is not limited to the constitutive activity of the receptor: promiscuity of ligands associated with and the capability of this receptor to instigate G protein sequestration also complicates the activity of cannabinoid receptor type 1. The therapeutic use of cannabinoid receptor type 1 agonists is still a heavily debated topic, making research on the mechanisms underlying the potential benefits and risks of cannabinoid use more vital than ever. Elucidation of these mechanisms and the quest for agonists and antagonists with greater specificity will allow a greater control of the side effects and risks involved in utilizing cannabinoids as therapeutic agents. In this chapter, we review a small subset of techniques used in the pharmacological application of and the behavioral effects of molecules acting at the paradoxical cannabinoid receptor type 1.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages28
Volume484
EditionC
DOIs
StatePublished - 2010

Publication series

NameMethods in Enzymology
No.C
Volume484
ISSN (Print)00766879

Fingerprint

Cannabinoid Receptor CB1
Cannabinoid Receptors
Cannabinoids
Cannabinoid Receptor Agonists
Biological Phenomena
Peripheral Nervous System
Therapeutic Uses
Appetite
GTP-Binding Proteins
Neurology
Central Nervous System
Learning
Pharmacology
Ligands
Pain
Data storage equipment
Molecules
Research

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Constitutive activity at the cannabinoid CB1 receptor and behavioral responses. / Hanlon, Katherine E.; Vanderah, Todd W.

C ed. Unknown Publisher, 2010. 28 p. (Methods in Enzymology; Vol. 484, No. C).

Research output: Book/ReportBook

Hanlon, Katherine E. ; Vanderah, Todd W. / Constitutive activity at the cannabinoid CB1 receptor and behavioral responses. C ed. Unknown Publisher, 2010. 28 p. (Methods in Enzymology; C).
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