Contact density affects protein evolutionary rate from bacteria to animals

Tong Zhou, D. Allan Drummond, Claus O. Wilke

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The density of contacts or the fraction of buried sites in a protein structure is thought to be related to a protein's designability, and genes encoding more designable proteins should evolve faster than other genes. Several recent studies have tested this hypothesis but have found conflicting results. Here, we investigate how a gene's evolutionary rate is affected by its protein's contact density, considering the four species Escherichia coli, Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens. We find for all four species that contact density correlates positively with evolutionary rate, and that these correlations do not seem to be confounded by gene expression level. The strength of this signal, however, varies widely among species. We also study the effect of contact density on domain evolution in multidomain proteins and find that a domain's contact density influences the domain's evolutionary rate. Within the same protein, a domain with higher contact density tends to evolve faster than a domain with lower contact density. Our study provides evidence that contact density can increase evolutionary rates, and that it acts similarly on the level of entire proteins and of individual protein domains.

Original languageEnglish (US)
Pages (from-to)395-404
Number of pages10
JournalJournal of Molecular Evolution
Volume66
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Designability
  • Domain
  • Evolutionary rate
  • Principal component regression
  • Protein evolution
  • Protein structure

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Contact density affects protein evolutionary rate from bacteria to animals'. Together they form a unique fingerprint.

  • Cite this