Continuous-flow solid-phase peptide synthesis

Viktor Krchňák, Josef Vágner, Martin Flegel, Otakar Mach

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

Original languageEnglish (US)
Pages (from-to)4469-4472
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number38
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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