Continuous-flow solid-phase peptide synthesis

Viktor Krchňák, Josef Vagner, Martin Flegel, Otakar Mach

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

Original languageEnglish (US)
Pages (from-to)4469-4472
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number38
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Solid-Phase Synthesis Techniques
Peptides
Polystyrenes
Amides
Pressure
Resins

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Continuous-flow solid-phase peptide synthesis. / Krchňák, Viktor; Vagner, Josef; Flegel, Martin; Mach, Otakar.

In: Tetrahedron Letters, Vol. 28, No. 38, 1987, p. 4469-4472.

Research output: Contribution to journalArticle

Krchňák, Viktor ; Vagner, Josef ; Flegel, Martin ; Mach, Otakar. / Continuous-flow solid-phase peptide synthesis. In: Tetrahedron Letters. 1987 ; Vol. 28, No. 38. pp. 4469-4472.
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