Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity.

J. Vágner, P. Kocna, V. Krchnák

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalPeptide research
Volume4
Issue number5
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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