Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy

Adriana Weinberg, Ruth Dickover, Paula Britto, Chengcheng Hu, Julie Patterson-Bartlett, Joyce Kraimer, Howard Gutzman, William T. Shearer, Mobeen Rathore, Ross McKinney, Katherine Knapp, Jill Utech, Sandra Jones, James McCauley, Maureen Haak, Rolando Viani, Anita Darcey, Carole Mathison, Yong I I Choi, Jean Hurwitz & 38 others Juliana Simonetti, Maxine Frere, Susan Champion, Leonard B. Weiner, Kathie A. Contello, Wendy Holz, Maureen Famiglietti, Gwendolyn B. Scott, Charles D. Mitchell, Liset Taybo, Sylvia Willumsen, Ayesha Mirza, Ana Alvarez, Saniyyah Mahmoudi, Kathy Thoma, Mark Abzug, Emily Barr, Suzanne Paul, Sandra Burchett, Catherine Kneut, Nancy Calles, Chivon Jackson, Mary E. Paul, Diane W. Wara, Deborah Trevithick, Nagamah Deygoo, William Borkowsky, Sulachni Chandwani, Siham Akleh, Eleanor Jiménez, Midnela Acevedo, Isis Moraima Burgos, Lizbeth Fábregas, Irma L. Febo Rodriguez, Ruth E. Santos Otero, Maritza Cruz, Lisette Lugo, Katherine Luzuriaga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: The goal of HAART is to promote reconstitution of CD4 + T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART. Methods: Thirty-seven children receiving their first HAART regimen had plasma HIV RNA; T cells and subpopulations; T-cell rearrangement excision circles (TREC) DNA; Candida, HIVCD4 and HIVCD8 enzyme-linked immunospot measured at regular intervals. Results: Plasma HIV RNA became undetectable in 81% of patients at 24 weeks and remained undetectable in 77% at 144 weeks. In contrast, CD4+% continuously increased. Distribution of T-cell subpopulations changed rapidly during the first 48 weeks of HAART and more slowly thereafter. At 144 weeks, total, naive and activated CD4+% and naive CD8+% of HIV-infected children were not significantly different from those of healthy age-matched controls, whereas total and activated CD8+% remained elevated. CD4+ and CD8+ TREC content increased only during the first 48 weeks of HAART. They positively correlated with each other and with total CD4+%, naive CD4+% and naive CD8+%. Candida and HIVCD4 enzyme-linked immunospot increased over time reaching peak values at 48 weeks and 144 weeks, respectively. HIVCD8 enzyme-linked immunospot decreased in magnitude over 144 weeks of HAART but retained its breadth. Baseline CD4+% positively correlated with CD4+% and with functional immune reconstitution at week 144, whereas baseline TREC correlated with TREC at week 144. Conclusion: HIV-infected children acquired normal distribution of CD4+ T cells and other subpopulations and recovered CD4-mediated HIV immunity after 144 weeks of HAART.

Original languageEnglish (US)
Pages (from-to)2267-2277
Number of pages11
JournalAIDS
Volume22
Issue number17
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Highly Active Antiretroviral Therapy
Immune System
HIV
T-Lymphocytes
Therapeutics
Candida
Enzymes
RNA
Normal Distribution
Immunity
DNA

Keywords

  • Candida
  • Cell-mediated immunity
  • Children
  • Highly active antiretroviral therapy
  • HIV
  • T-cell rearrangement excision circle
  • T-cell subpopulations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Weinberg, A., Dickover, R., Britto, P., Hu, C., Patterson-Bartlett, J., Kraimer, J., ... Luzuriaga, K. (2008). Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy. AIDS, 22(17), 2267-2277. https://doi.org/10.1097/QAD.0b013e3283189bb3

Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy. / Weinberg, Adriana; Dickover, Ruth; Britto, Paula; Hu, Chengcheng; Patterson-Bartlett, Julie; Kraimer, Joyce; Gutzman, Howard; Shearer, William T.; Rathore, Mobeen; McKinney, Ross; Knapp, Katherine; Utech, Jill; Jones, Sandra; McCauley, James; Haak, Maureen; Viani, Rolando; Darcey, Anita; Mathison, Carole; Choi, Yong I I; Hurwitz, Jean; Simonetti, Juliana; Frere, Maxine; Champion, Susan; Weiner, Leonard B.; Contello, Kathie A.; Holz, Wendy; Famiglietti, Maureen; Scott, Gwendolyn B.; Mitchell, Charles D.; Taybo, Liset; Willumsen, Sylvia; Mirza, Ayesha; Alvarez, Ana; Mahmoudi, Saniyyah; Thoma, Kathy; Abzug, Mark; Barr, Emily; Paul, Suzanne; Burchett, Sandra; Kneut, Catherine; Calles, Nancy; Jackson, Chivon; Paul, Mary E.; Wara, Diane W.; Trevithick, Deborah; Deygoo, Nagamah; Borkowsky, William; Chandwani, Sulachni; Akleh, Siham; Jiménez, Eleanor; Acevedo, Midnela; Burgos, Isis Moraima; Fábregas, Lizbeth; Febo Rodriguez, Irma L.; Santos Otero, Ruth E.; Cruz, Maritza; Lugo, Lisette; Luzuriaga, Katherine.

In: AIDS, Vol. 22, No. 17, 2008, p. 2267-2277.

Research output: Contribution to journalArticle

Weinberg, A, Dickover, R, Britto, P, Hu, C, Patterson-Bartlett, J, Kraimer, J, Gutzman, H, Shearer, WT, Rathore, M, McKinney, R, Knapp, K, Utech, J, Jones, S, McCauley, J, Haak, M, Viani, R, Darcey, A, Mathison, C, Choi, YII, Hurwitz, J, Simonetti, J, Frere, M, Champion, S, Weiner, LB, Contello, KA, Holz, W, Famiglietti, M, Scott, GB, Mitchell, CD, Taybo, L, Willumsen, S, Mirza, A, Alvarez, A, Mahmoudi, S, Thoma, K, Abzug, M, Barr, E, Paul, S, Burchett, S, Kneut, C, Calles, N, Jackson, C, Paul, ME, Wara, DW, Trevithick, D, Deygoo, N, Borkowsky, W, Chandwani, S, Akleh, S, Jiménez, E, Acevedo, M, Burgos, IM, Fábregas, L, Febo Rodriguez, IL, Santos Otero, RE, Cruz, M, Lugo, L & Luzuriaga, K 2008, 'Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy', AIDS, vol. 22, no. 17, pp. 2267-2277. https://doi.org/10.1097/QAD.0b013e3283189bb3
Weinberg, Adriana ; Dickover, Ruth ; Britto, Paula ; Hu, Chengcheng ; Patterson-Bartlett, Julie ; Kraimer, Joyce ; Gutzman, Howard ; Shearer, William T. ; Rathore, Mobeen ; McKinney, Ross ; Knapp, Katherine ; Utech, Jill ; Jones, Sandra ; McCauley, James ; Haak, Maureen ; Viani, Rolando ; Darcey, Anita ; Mathison, Carole ; Choi, Yong I I ; Hurwitz, Jean ; Simonetti, Juliana ; Frere, Maxine ; Champion, Susan ; Weiner, Leonard B. ; Contello, Kathie A. ; Holz, Wendy ; Famiglietti, Maureen ; Scott, Gwendolyn B. ; Mitchell, Charles D. ; Taybo, Liset ; Willumsen, Sylvia ; Mirza, Ayesha ; Alvarez, Ana ; Mahmoudi, Saniyyah ; Thoma, Kathy ; Abzug, Mark ; Barr, Emily ; Paul, Suzanne ; Burchett, Sandra ; Kneut, Catherine ; Calles, Nancy ; Jackson, Chivon ; Paul, Mary E. ; Wara, Diane W. ; Trevithick, Deborah ; Deygoo, Nagamah ; Borkowsky, William ; Chandwani, Sulachni ; Akleh, Siham ; Jiménez, Eleanor ; Acevedo, Midnela ; Burgos, Isis Moraima ; Fábregas, Lizbeth ; Febo Rodriguez, Irma L. ; Santos Otero, Ruth E. ; Cruz, Maritza ; Lugo, Lisette ; Luzuriaga, Katherine. / Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy. In: AIDS. 2008 ; Vol. 22, No. 17. pp. 2267-2277.
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abstract = "Background: The goal of HAART is to promote reconstitution of CD4 + T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART. Methods: Thirty-seven children receiving their first HAART regimen had plasma HIV RNA; T cells and subpopulations; T-cell rearrangement excision circles (TREC) DNA; Candida, HIVCD4 and HIVCD8 enzyme-linked immunospot measured at regular intervals. Results: Plasma HIV RNA became undetectable in 81{\%} of patients at 24 weeks and remained undetectable in 77{\%} at 144 weeks. In contrast, CD4+{\%} continuously increased. Distribution of T-cell subpopulations changed rapidly during the first 48 weeks of HAART and more slowly thereafter. At 144 weeks, total, naive and activated CD4+{\%} and naive CD8+{\%} of HIV-infected children were not significantly different from those of healthy age-matched controls, whereas total and activated CD8+{\%} remained elevated. CD4+ and CD8+ TREC content increased only during the first 48 weeks of HAART. They positively correlated with each other and with total CD4+{\%}, naive CD4+{\%} and naive CD8+{\%}. Candida and HIVCD4 enzyme-linked immunospot increased over time reaching peak values at 48 weeks and 144 weeks, respectively. HIVCD8 enzyme-linked immunospot decreased in magnitude over 144 weeks of HAART but retained its breadth. Baseline CD4+{\%} positively correlated with CD4+{\%} and with functional immune reconstitution at week 144, whereas baseline TREC correlated with TREC at week 144. Conclusion: HIV-infected children acquired normal distribution of CD4+ T cells and other subpopulations and recovered CD4-mediated HIV immunity after 144 weeks of HAART.",
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T1 - Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy

AU - Weinberg, Adriana

AU - Dickover, Ruth

AU - Britto, Paula

AU - Hu, Chengcheng

AU - Patterson-Bartlett, Julie

AU - Kraimer, Joyce

AU - Gutzman, Howard

AU - Shearer, William T.

AU - Rathore, Mobeen

AU - McKinney, Ross

AU - Knapp, Katherine

AU - Utech, Jill

AU - Jones, Sandra

AU - McCauley, James

AU - Haak, Maureen

AU - Viani, Rolando

AU - Darcey, Anita

AU - Mathison, Carole

AU - Choi, Yong I I

AU - Hurwitz, Jean

AU - Simonetti, Juliana

AU - Frere, Maxine

AU - Champion, Susan

AU - Weiner, Leonard B.

AU - Contello, Kathie A.

AU - Holz, Wendy

AU - Famiglietti, Maureen

AU - Scott, Gwendolyn B.

AU - Mitchell, Charles D.

AU - Taybo, Liset

AU - Willumsen, Sylvia

AU - Mirza, Ayesha

AU - Alvarez, Ana

AU - Mahmoudi, Saniyyah

AU - Thoma, Kathy

AU - Abzug, Mark

AU - Barr, Emily

AU - Paul, Suzanne

AU - Burchett, Sandra

AU - Kneut, Catherine

AU - Calles, Nancy

AU - Jackson, Chivon

AU - Paul, Mary E.

AU - Wara, Diane W.

AU - Trevithick, Deborah

AU - Deygoo, Nagamah

AU - Borkowsky, William

AU - Chandwani, Sulachni

AU - Akleh, Siham

AU - Jiménez, Eleanor

AU - Acevedo, Midnela

AU - Burgos, Isis Moraima

AU - Fábregas, Lizbeth

AU - Febo Rodriguez, Irma L.

AU - Santos Otero, Ruth E.

AU - Cruz, Maritza

AU - Lugo, Lisette

AU - Luzuriaga, Katherine

PY - 2008

Y1 - 2008

N2 - Background: The goal of HAART is to promote reconstitution of CD4 + T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART. Methods: Thirty-seven children receiving their first HAART regimen had plasma HIV RNA; T cells and subpopulations; T-cell rearrangement excision circles (TREC) DNA; Candida, HIVCD4 and HIVCD8 enzyme-linked immunospot measured at regular intervals. Results: Plasma HIV RNA became undetectable in 81% of patients at 24 weeks and remained undetectable in 77% at 144 weeks. In contrast, CD4+% continuously increased. Distribution of T-cell subpopulations changed rapidly during the first 48 weeks of HAART and more slowly thereafter. At 144 weeks, total, naive and activated CD4+% and naive CD8+% of HIV-infected children were not significantly different from those of healthy age-matched controls, whereas total and activated CD8+% remained elevated. CD4+ and CD8+ TREC content increased only during the first 48 weeks of HAART. They positively correlated with each other and with total CD4+%, naive CD4+% and naive CD8+%. Candida and HIVCD4 enzyme-linked immunospot increased over time reaching peak values at 48 weeks and 144 weeks, respectively. HIVCD8 enzyme-linked immunospot decreased in magnitude over 144 weeks of HAART but retained its breadth. Baseline CD4+% positively correlated with CD4+% and with functional immune reconstitution at week 144, whereas baseline TREC correlated with TREC at week 144. Conclusion: HIV-infected children acquired normal distribution of CD4+ T cells and other subpopulations and recovered CD4-mediated HIV immunity after 144 weeks of HAART.

AB - Background: The goal of HAART is to promote reconstitution of CD4 + T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART. Methods: Thirty-seven children receiving their first HAART regimen had plasma HIV RNA; T cells and subpopulations; T-cell rearrangement excision circles (TREC) DNA; Candida, HIVCD4 and HIVCD8 enzyme-linked immunospot measured at regular intervals. Results: Plasma HIV RNA became undetectable in 81% of patients at 24 weeks and remained undetectable in 77% at 144 weeks. In contrast, CD4+% continuously increased. Distribution of T-cell subpopulations changed rapidly during the first 48 weeks of HAART and more slowly thereafter. At 144 weeks, total, naive and activated CD4+% and naive CD8+% of HIV-infected children were not significantly different from those of healthy age-matched controls, whereas total and activated CD8+% remained elevated. CD4+ and CD8+ TREC content increased only during the first 48 weeks of HAART. They positively correlated with each other and with total CD4+%, naive CD4+% and naive CD8+%. Candida and HIVCD4 enzyme-linked immunospot increased over time reaching peak values at 48 weeks and 144 weeks, respectively. HIVCD8 enzyme-linked immunospot decreased in magnitude over 144 weeks of HAART but retained its breadth. Baseline CD4+% positively correlated with CD4+% and with functional immune reconstitution at week 144, whereas baseline TREC correlated with TREC at week 144. Conclusion: HIV-infected children acquired normal distribution of CD4+ T cells and other subpopulations and recovered CD4-mediated HIV immunity after 144 weeks of HAART.

KW - Candida

KW - Cell-mediated immunity

KW - Children

KW - Highly active antiretroviral therapy

KW - HIV

KW - T-cell rearrangement excision circle

KW - T-cell subpopulations

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