Continuous simultaneous detection in mass spectrometry

Gregory D. Schilling, Francisco J. Andrade, James H. Barnes IV, Roger P. Sperline, M Bonner Denton, Charles J. Barinaga, David W. Koppenaal, Gary M. Hieftje

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In mass spectrometry, several advantages can be derived when multiple mass-to-charge values are detected simultaneously and continuously. One such advantage is an improved duty cycle, which leads to superior limits of detection, better precision, shorter analysis times, and reduced sample sizes. A second advantage is the ability to reduce correlated noise by taking the ratio of two or more simultaneously collected signals, enabling greatly enhanced isotope ratio data. A final advantage is the elimination of spectral skew, leading to more accurate transient signal analysis. Here, these advantages are demonstrated by means of a novel Faraday-strip array detector coupled to a Mattauch-Herzog mass spectrograph. The same system is used to monitor elemental fractionation phenomena in laser ablation inductively coupled plasma mass spectrometry.

Original languageEnglish (US)
Pages (from-to)7662-7668
Number of pages7
JournalAnalytical Chemistry
Volume79
Issue number20
DOIs
StatePublished - Oct 15 2007

Fingerprint

Inductively coupled plasma mass spectrometry
Spectrographs
Signal analysis
Laser ablation
Fractionation
Isotopes
Mass spectrometry
Detectors

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Schilling, G. D., Andrade, F. J., Barnes IV, J. H., Sperline, R. P., Denton, M. B., Barinaga, C. J., ... Hieftje, G. M. (2007). Continuous simultaneous detection in mass spectrometry. Analytical Chemistry, 79(20), 7662-7668. https://doi.org/10.1021/ac070785s

Continuous simultaneous detection in mass spectrometry. / Schilling, Gregory D.; Andrade, Francisco J.; Barnes IV, James H.; Sperline, Roger P.; Denton, M Bonner; Barinaga, Charles J.; Koppenaal, David W.; Hieftje, Gary M.

In: Analytical Chemistry, Vol. 79, No. 20, 15.10.2007, p. 7662-7668.

Research output: Contribution to journalArticle

Schilling, GD, Andrade, FJ, Barnes IV, JH, Sperline, RP, Denton, MB, Barinaga, CJ, Koppenaal, DW & Hieftje, GM 2007, 'Continuous simultaneous detection in mass spectrometry', Analytical Chemistry, vol. 79, no. 20, pp. 7662-7668. https://doi.org/10.1021/ac070785s
Schilling GD, Andrade FJ, Barnes IV JH, Sperline RP, Denton MB, Barinaga CJ et al. Continuous simultaneous detection in mass spectrometry. Analytical Chemistry. 2007 Oct 15;79(20):7662-7668. https://doi.org/10.1021/ac070785s
Schilling, Gregory D. ; Andrade, Francisco J. ; Barnes IV, James H. ; Sperline, Roger P. ; Denton, M Bonner ; Barinaga, Charles J. ; Koppenaal, David W. ; Hieftje, Gary M. / Continuous simultaneous detection in mass spectrometry. In: Analytical Chemistry. 2007 ; Vol. 79, No. 20. pp. 7662-7668.
@article{02ec9813b2c44d29acdcf19f7881dc31,
title = "Continuous simultaneous detection in mass spectrometry",
abstract = "In mass spectrometry, several advantages can be derived when multiple mass-to-charge values are detected simultaneously and continuously. One such advantage is an improved duty cycle, which leads to superior limits of detection, better precision, shorter analysis times, and reduced sample sizes. A second advantage is the ability to reduce correlated noise by taking the ratio of two or more simultaneously collected signals, enabling greatly enhanced isotope ratio data. A final advantage is the elimination of spectral skew, leading to more accurate transient signal analysis. Here, these advantages are demonstrated by means of a novel Faraday-strip array detector coupled to a Mattauch-Herzog mass spectrograph. The same system is used to monitor elemental fractionation phenomena in laser ablation inductively coupled plasma mass spectrometry.",
author = "Schilling, {Gregory D.} and Andrade, {Francisco J.} and {Barnes IV}, {James H.} and Sperline, {Roger P.} and Denton, {M Bonner} and Barinaga, {Charles J.} and Koppenaal, {David W.} and Hieftje, {Gary M.}",
year = "2007",
month = "10",
day = "15",
doi = "10.1021/ac070785s",
language = "English (US)",
volume = "79",
pages = "7662--7668",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "20",

}

TY - JOUR

T1 - Continuous simultaneous detection in mass spectrometry

AU - Schilling, Gregory D.

AU - Andrade, Francisco J.

AU - Barnes IV, James H.

AU - Sperline, Roger P.

AU - Denton, M Bonner

AU - Barinaga, Charles J.

AU - Koppenaal, David W.

AU - Hieftje, Gary M.

PY - 2007/10/15

Y1 - 2007/10/15

N2 - In mass spectrometry, several advantages can be derived when multiple mass-to-charge values are detected simultaneously and continuously. One such advantage is an improved duty cycle, which leads to superior limits of detection, better precision, shorter analysis times, and reduced sample sizes. A second advantage is the ability to reduce correlated noise by taking the ratio of two or more simultaneously collected signals, enabling greatly enhanced isotope ratio data. A final advantage is the elimination of spectral skew, leading to more accurate transient signal analysis. Here, these advantages are demonstrated by means of a novel Faraday-strip array detector coupled to a Mattauch-Herzog mass spectrograph. The same system is used to monitor elemental fractionation phenomena in laser ablation inductively coupled plasma mass spectrometry.

AB - In mass spectrometry, several advantages can be derived when multiple mass-to-charge values are detected simultaneously and continuously. One such advantage is an improved duty cycle, which leads to superior limits of detection, better precision, shorter analysis times, and reduced sample sizes. A second advantage is the ability to reduce correlated noise by taking the ratio of two or more simultaneously collected signals, enabling greatly enhanced isotope ratio data. A final advantage is the elimination of spectral skew, leading to more accurate transient signal analysis. Here, these advantages are demonstrated by means of a novel Faraday-strip array detector coupled to a Mattauch-Herzog mass spectrograph. The same system is used to monitor elemental fractionation phenomena in laser ablation inductively coupled plasma mass spectrometry.

UR - http://www.scopus.com/inward/record.url?scp=35448993903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448993903&partnerID=8YFLogxK

U2 - 10.1021/ac070785s

DO - 10.1021/ac070785s

M3 - Article

C2 - 17877420

AN - SCOPUS:35448993903

VL - 79

SP - 7662

EP - 7668

JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

IS - 20

ER -