Continuum models for liposome and macromolecular drug transport in tissue

Research output: Contribution to conferencePaper

Abstract

The effective transport properties for macromolecules and liposomes in tissue are determined with respect to their importance on the delivery of sufficient quantities of anti-cancer drugs to tumor regions. Transport of liposomes which are not small compared to the gaps between cells, differs from transport of macromolecules. The hydrodynamic mobility of liposomes is decreased by the proximity to cell walls, hence resulting to smaller effective diffusivity. In channels between irregularly shaped cells where the channel width is variable, coupling between diffusion and convection of liposomes arises from migration across fluid streamlines, leading to non-uniform concentration distributions across the channels.

Original languageEnglish (US)
Pages189-190
Number of pages2
StatePublished - Jan 1 1995
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period6/28/957/2/95

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    El-Kareh, A. W., & Secomb, T. W. (1995). Continuum models for liposome and macromolecular drug transport in tissue. 189-190. Paper presented at Proceedings of the 1995 Bioengineering Conference, Beever Creek, CO, USA, .