Contractility of strips of renal cortex obtained from rabbit kidneys obstructed by complete ureteral ligation for 8 and 32 days was tested and compared with control tissue. Concentration-response data were obtained for norepinephrine, angio-tensin, and 5-hydroxytryptamine, and were expressed as mg tension/cm of tissue. Control tissue tested simultaneously revealed minimal responses, but obstructed tissue containing modified interstitial cells revealed statistically significant evidence of contraction in response to all three drugs studied. The response to norepinephrine could be blocked by the alpha adrenergic antagonist, phenoxybenzamine, but this drug did not significantly affect the response to angio-tensin or 5-hydroxytryptamine. The findings are related to similar observations reported in stimulated fibroblasts of granulation tissue and are discussed in terms of the possible role this phenomenon may play in the patho-genesis of renal interstitial injury.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Mar 1975|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)