Contractility of renal cortex following complete ureteral obstruction

Raymond B Nagle, L. W. Evans, D. G. Reynolds

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Contractility of strips of renal cortex obtained from rabbit kidneys obstructed by complete ureteral ligation for 8 and 32 days was tested and compared with control tissue. Concentration response data were obtained for norepinephrine, angiotensin, and 5 hydroxytryptamine, and were expressed as mg tension/cm of tissue. Control tissue tested simultaneously revealed minimal responses, but obstructed tissue containing modified interstitial cells revealed statistically significant evidence of contraction in response to all 3 drugs studied. The response to norepinephrine could be blocked by the alpha adrenergic antagonist, phenoxybenzamine, but this drug did not significantly affect the response to angiotensin or 5 hydroxytryptamine. The findings are related to similr observations reported in stimulated fibroblasts of granulation tissue and are discussed in terms of the possible role this phenomenon may play in the pathogenesis of renal interstitial injury.

Original languageEnglish (US)
Pages (from-to)611-614
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume148
Issue number3
StatePublished - 1975
Externally publishedYes

Fingerprint

Ureteral Obstruction
Tissue
Kidney
Angiotensins
Serotonin
Norepinephrine
Adrenergic alpha-Antagonists
Phenoxybenzamine
Granulation Tissue
Pharmaceutical Preparations
Granulation
Ligation
Fibroblasts
Rabbits
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Contractility of renal cortex following complete ureteral obstruction. / Nagle, Raymond B; Evans, L. W.; Reynolds, D. G.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 148, No. 3, 1975, p. 611-614.

Research output: Contribution to journalArticle

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