Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

Beatriz Parra, Mark T. Lin, Stephen A. Stohlman, Cornelia C. Bergmann, Roscoe Atkinson, David R. Hinton

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Abstract

The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

Original languageEnglish (US)
Pages (from-to)2447-2450
Number of pages4
JournalJournal of virology
Volume74
Issue number5
DOIs
StatePublished - Feb 23 2000

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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