Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

Beatriz Parra, Mark T Lin, Stephen A. Stohlman, Cornelia C. Bergmann, Roscoe Atkinson, David R. Hinton

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

Original languageEnglish (US)
Pages (from-to)2447-2450
Number of pages4
JournalJournal of Virology
Volume74
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

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Murine hepatitis virus
Perforin
Fas Ligand Protein
central nervous system
cytotoxicity
pathogenesis
Central Nervous System
cytolysis
Virus Replication
virus replication
mice
Infection
infection
ligands

ASJC Scopus subject areas

  • Immunology

Cite this

Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. / Parra, Beatriz; Lin, Mark T; Stohlman, Stephen A.; Bergmann, Cornelia C.; Atkinson, Roscoe; Hinton, David R.

In: Journal of Virology, Vol. 74, No. 5, 2000, p. 2447-2450.

Research output: Contribution to journalArticle

Parra, Beatriz ; Lin, Mark T ; Stohlman, Stephen A. ; Bergmann, Cornelia C. ; Atkinson, Roscoe ; Hinton, David R. / Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. In: Journal of Virology. 2000 ; Vol. 74, No. 5. pp. 2447-2450.
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