Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae

Ted Weinert, L. Hartwell

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a 'checkpoint'. Four additional genes have been identified that are also components of the RAD9 checkpoint.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalJournal of Cell Science
Volume94
Issue numberSUPPL. 12
StatePublished - 1989
Externally publishedYes

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DNA Replication
Saccharomyces cerevisiae
G2 Phase
Cell Cycle Checkpoints
Mitosis
Genes
DNA Damage
Cell Cycle
Temperature

ASJC Scopus subject areas

  • Cell Biology

Cite this

Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae. / Weinert, Ted; Hartwell, L.

In: Journal of Cell Science, Vol. 94, No. SUPPL. 12, 1989, p. 145-148.

Research output: Contribution to journalArticle

Weinert, Ted ; Hartwell, L. / Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae. In: Journal of Cell Science. 1989 ; Vol. 94, No. SUPPL. 12. pp. 145-148.
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