Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae

T. Weinert, L. Hartwell

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a 'checkpoint'. Four additional genes have been identified that are also components of the RAD9 checkpoint.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalJournal of Cell Science
Volume94
Issue numberSUPPL. 12
StatePublished - Dec 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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