Controlled delivery of pilocarpine. 1. In vitro characterization of Gelfoam® matrices

S. R. Nadkarni, Samuel H Yalkowsky

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The potential of Gelfoam absorbable gelatin sponge as a carrier for ophthalmic delivery of pilocarpine was examined. Prolonged in vitro release of pilocarpine was achieved through pharmaceutical modification of the device by embedding a retardant in the pores. The device embedded with cetyl ester wax released pilocarpine in a zero-order pattern (release exponent = 0.93 ± 0.04) for up to 5 hr. This result corresponded well with a linear penetrant uptake by this device. The device impregnated with polyethylene glycol 400 monostearate exhibited anomalous drug transport with a release exponent of 0.63 ± 0.02. The absorption of water by this retardant and the formation of a gel layer on the surface slowed the penetration of the release medium into the deeper sections of the matrix, as well as the rapid outward diffusion of drug, resulting in a prolonged release of pilocarpine.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalPharmaceutical Research
Volume10
Issue number1
DOIs
StatePublished - 1993

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Absorbable Gelatin Sponge
Pilocarpine
Equipment and Supplies
Pharmaceutical Preparations
Waxes
Gelatin
Esters
Gels
In Vitro Techniques
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmaceutical Science
  • Pharmacology

Cite this

Controlled delivery of pilocarpine. 1. In vitro characterization of Gelfoam® matrices. / Nadkarni, S. R.; Yalkowsky, Samuel H.

In: Pharmaceutical Research, Vol. 10, No. 1, 1993, p. 109-112.

Research output: Contribution to journalArticle

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