Convective diffusional analysis for drug transport through a tubular polymeric membrane

D. R. Flanagan, Samuel H Yalkowsky

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The transport of three p-aminobenzoate esters (ethyl, butyl, and hexyl) through a tubular dimethyl polysiloxane membrane into a flowing liquid was investigated. The tubular configuration permits the exact determination of the convective diffusional contribution to membrane transport with models that account for fluid hydrodynamics. The observed transport behavior ranged from complete convective diffusion control for the hexyl ester to complete membrane control for the ethyl ester; the butyl ester exhibited a change in control with flow rate. The implications of convective diffusional considerations to intestinal absorption and dissolution studies are discussed.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume66
Issue number3
StatePublished - 1977
Externally publishedYes

Fingerprint

Polymeric membranes
Esters
Membranes
Pharmaceutical Preparations
para-Aminobenzoates
Intestinal Absorption
Hydrodynamics
Dissolution
Flow rate
Fluids
Liquids

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Convective diffusional analysis for drug transport through a tubular polymeric membrane. / Flanagan, D. R.; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 66, No. 3, 1977, p. 337-340.

Research output: Contribution to journalArticle

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