Conversion in the peptides coating cadmium: sulfide crystallites in Candida glabrata

J. Barbas, Walther R Ellis, V. Santhanagopalan, M. Blaszczynski, D. R. Winge

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cultures of Candida glabrata treated with CdCl2 form intracellular Cd(II) complexes that evolve with the time of culturing. Initially, glutathione (γECG) appears to be the major buffering component. One type of Cd(II)-glutathione complex exists as a cadmium:sulfide (CdS) crystallite coated with glutathione. A time dependent change in the coating of the CdS particles occurs with a decrease in the (γECG) content and a corresponding increase in the abundance of (γEC)nG peptides with (γEC)2G becoming the predominant peptide. The desGly variant (γEC)2 appears in significant concentration only in late cultures. The evolution in isopeptide coating appears to be dependent on the sulfide content of the CdS particles. Cellular conditions that enhance the generation of sulfide ions facilitate the conversion from γECG to (γEC)2G.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalJournal of Inorganic Biochemistry
Volume48
Issue number2
DOIs
StatePublished - Nov 1 1992
Externally publishedYes

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Candida glabrata
Candida
Electrocardiography
Crystallites
Glutathione
Sulfides
Coatings
Peptides
Cadmium Chloride
Ions
cadmium sulfide

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Conversion in the peptides coating cadmium : sulfide crystallites in Candida glabrata. / Barbas, J.; Ellis, Walther R; Santhanagopalan, V.; Blaszczynski, M.; Winge, D. R.

In: Journal of Inorganic Biochemistry, Vol. 48, No. 2, 01.11.1992, p. 95-105.

Research output: Contribution to journalArticle

Barbas, J. ; Ellis, Walther R ; Santhanagopalan, V. ; Blaszczynski, M. ; Winge, D. R. / Conversion in the peptides coating cadmium : sulfide crystallites in Candida glabrata. In: Journal of Inorganic Biochemistry. 1992 ; Vol. 48, No. 2. pp. 95-105.
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