Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels

J. F. Black, Jennifer K Barton, G. Frangineas, H. Pummer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

A novel laser system has been developed to study the effects of multiple laser pulses of differing wavelengths on cutaneous blood vessels in vivo, using the hamster dorsal skin flap preparation. The system permits sequenced irradiation with well-defined intrapulse spacing at 532 nm, using a long pulse frequency doubled Nd:YAG laser, and at 1064 nm, using a long pulse Nd:YAG laser. Using this system, we have identified a parameter space where two pulses of different wavelengths act in a synergistic manner to effect permanent vessel damage at radiant exposures where the two pulses individually have little or no effect. Using a two-color pump-probe technique in vitro, we have identified a phenomenon we call green-light-induced infrared absorption (GLIIRA), where a pulse of green light causes photochemical and photothermal modifications to the chemical constituents of blood and results in enhanced infrared absorption. We identify a new chemical species, met-hemoglobin, not normally present in healthy human blood but formed during laser photocoagulation which we believe is implicated in the enhanced IR absorption.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsR.R. Anderson, K.E. Bartels, L.S. Bass, C.G. Garrett
Pages13-24
Number of pages12
Volume4244
DOIs
StatePublished - 2001
EventLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI - San Jose,CA, United States
Duration: Jun 20 2001Jun 23 2001

Other

OtherLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI
CountryUnited States
CitySan Jose,CA
Period6/20/016/23/01

Fingerprint

blood vessels
Blood vessels
Laser pulses
Color
color
Lasers
Infrared absorption
pulses
lasers
Blood
Wavelength
infrared absorption
blood
YAG lasers
Hemoglobin
Skin
hamsters
hemoglobin
Irradiation
Pumps

Keywords

  • Hemoglobin
  • Met-hemoglobin
  • Nd:YAG laser
  • Oxy-hemoglobin
  • Selective photothermolysis
  • Telangiectases

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Black, J. F., Barton, J. K., Frangineas, G., & Pummer, H. (2001). Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels. In R. R. Anderson, K. E. Bartels, L. S. Bass, & C. G. Garrett (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4244, pp. 13-24) https://doi.org/10.1117/12.427786

Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels. / Black, J. F.; Barton, Jennifer K; Frangineas, G.; Pummer, H.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / R.R. Anderson; K.E. Bartels; L.S. Bass; C.G. Garrett. Vol. 4244 2001. p. 13-24.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Black, JF, Barton, JK, Frangineas, G & Pummer, H 2001, Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels. in RR Anderson, KE Bartels, LS Bass & CG Garrett (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4244, pp. 13-24, Laser in Surgery: Advanced Characterization, Therapeutics, and Systems XI, San Jose,CA, United States, 6/20/01. https://doi.org/10.1117/12.427786
Black JF, Barton JK, Frangineas G, Pummer H. Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels. In Anderson RR, Bartels KE, Bass LS, Garrett CG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4244. 2001. p. 13-24 https://doi.org/10.1117/12.427786
Black, J. F. ; Barton, Jennifer K ; Frangineas, G. ; Pummer, H. / Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels. Proceedings of SPIE - The International Society for Optical Engineering. editor / R.R. Anderson ; K.E. Bartels ; L.S. Bass ; C.G. Garrett. Vol. 4244 2001. pp. 13-24
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