Core-shell nanofibers: Integrating the bioactivity of gelatin and the mechanical property of polyvinyl alcohol

Valerie M. Merkle, Like Zeng, Marvin J Slepian, Xiaoyi Wu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Coaxial electrospinning is used to fabricate nanofibers with gelatin in the shell and polyvinyl alcohol (PVA) in the core in order to derive mechanical strength from PVA and bioactivity from gelatin. At a 1:1 PVA/gelatin mass ratio, the core-shell nanofiber scaffolds display a Young's modulus of 168.6 6 36.5 MPa and a tensile strength of 5.42 6 1.95 MPa, which are significantly higher than those of the scaffolds composed solely of gelatin or PVA. The Young's modulus and tensile strength of the coreshell nanofibers are further improved by reducing the PVA/gelatin mass ratio from 1:1 to 1:3. The mechanical analysis of the core-shell nanofibers suggests that the presence of the gelatin shell may improve the molecular alignment of the PVA core, transforming the semi-crystalline, plastic PVA into a more crystallized, elastic PVA, and enhancing the mechanical properties of the core. Lastly, the PVA/gelatin core-shell nanofibers possess cellular viability, proliferation, and adhesion similar to these of the gelatin nanofibers, and show significantly higher proliferation and adhesion than the PVA nanofibers. Taken together, the coaxial electrospinning of nanofibers with a core-shell structure permits integration of the bioactivity of gelatin and the mechanical strength of PVA in single fibers.

Original languageEnglish (US)
Pages (from-to)336-346
Number of pages11
JournalBiopolymers - Peptide Science Section
Volume101
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Nanofibers
Polyvinyl Alcohol
Polyvinyl alcohols
Gelatin
Bioactivity
Mechanical properties
Tensile Strength
Elastic Modulus
Electrospinning
Scaffolds
Strength of materials
Tensile strength
Adhesion
Elastic moduli
Molecular orientation
Plastics

Keywords

  • Coaxial Electrospinning
  • Core-Shell Nanofibers
  • Gelatin
  • Polyvinyl Alcohol
  • Tissue Engineering

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biomaterials
  • Organic Chemistry

Cite this

Core-shell nanofibers : Integrating the bioactivity of gelatin and the mechanical property of polyvinyl alcohol. / Merkle, Valerie M.; Zeng, Like; Slepian, Marvin J; Wu, Xiaoyi.

In: Biopolymers - Peptide Science Section, Vol. 101, No. 4, 2014, p. 336-346.

Research output: Contribution to journalArticle

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