Coronary flow reserve

A. James Bradley, Joseph S Alpert

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The ability of the coronary circulation to autoregulate is essential for the heart to respond to metabolic demands. Several alterations in function may limit maximal coronary perfusion including atherosclerosis, structural abnormalities of small coronary vessels, extravascular compressive forces, thrombosis, abnormal endothelial regulatory function, and the effect of abnormal myocardium on the coronary circulation. Coronary flow reserve is a unifying concept that examines the limitation in myocardial perfusion that certain disease states impose. At present, even with state-of-the-art technology, the measurement of coronary flow reserve is difficult in routine clinical situations. As the ability to measure regional myocardial perfusion improves, coronary flow reserve may gain more widespread clinical use with perhaps as yet undiscovered therapeutic implications.

Original languageEnglish (US)
Pages (from-to)1116-1128
Number of pages13
JournalAmerican Heart Journal
Volume122
Issue number4 PART 1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Coronary Circulation
Perfusion
Atherosclerosis
Coronary Vessels
Myocardium
Thrombosis
Technology
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary flow reserve. / Bradley, A. James; Alpert, Joseph S.

In: American Heart Journal, Vol. 122, No. 4 PART 1, 1991, p. 1116-1128.

Research output: Contribution to journalArticle

Bradley, A. James ; Alpert, Joseph S. / Coronary flow reserve. In: American Heart Journal. 1991 ; Vol. 122, No. 4 PART 1. pp. 1116-1128.
@article{64560b1116614ebe8b1bee9709c6e53a,
title = "Coronary flow reserve",
abstract = "The ability of the coronary circulation to autoregulate is essential for the heart to respond to metabolic demands. Several alterations in function may limit maximal coronary perfusion including atherosclerosis, structural abnormalities of small coronary vessels, extravascular compressive forces, thrombosis, abnormal endothelial regulatory function, and the effect of abnormal myocardium on the coronary circulation. Coronary flow reserve is a unifying concept that examines the limitation in myocardial perfusion that certain disease states impose. At present, even with state-of-the-art technology, the measurement of coronary flow reserve is difficult in routine clinical situations. As the ability to measure regional myocardial perfusion improves, coronary flow reserve may gain more widespread clinical use with perhaps as yet undiscovered therapeutic implications.",
author = "Bradley, {A. James} and Alpert, {Joseph S}",
year = "1991",
doi = "10.1016/0002-8703(91)90480-6",
language = "English (US)",
volume = "122",
pages = "1116--1128",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "4 PART 1",

}

TY - JOUR

T1 - Coronary flow reserve

AU - Bradley, A. James

AU - Alpert, Joseph S

PY - 1991

Y1 - 1991

N2 - The ability of the coronary circulation to autoregulate is essential for the heart to respond to metabolic demands. Several alterations in function may limit maximal coronary perfusion including atherosclerosis, structural abnormalities of small coronary vessels, extravascular compressive forces, thrombosis, abnormal endothelial regulatory function, and the effect of abnormal myocardium on the coronary circulation. Coronary flow reserve is a unifying concept that examines the limitation in myocardial perfusion that certain disease states impose. At present, even with state-of-the-art technology, the measurement of coronary flow reserve is difficult in routine clinical situations. As the ability to measure regional myocardial perfusion improves, coronary flow reserve may gain more widespread clinical use with perhaps as yet undiscovered therapeutic implications.

AB - The ability of the coronary circulation to autoregulate is essential for the heart to respond to metabolic demands. Several alterations in function may limit maximal coronary perfusion including atherosclerosis, structural abnormalities of small coronary vessels, extravascular compressive forces, thrombosis, abnormal endothelial regulatory function, and the effect of abnormal myocardium on the coronary circulation. Coronary flow reserve is a unifying concept that examines the limitation in myocardial perfusion that certain disease states impose. At present, even with state-of-the-art technology, the measurement of coronary flow reserve is difficult in routine clinical situations. As the ability to measure regional myocardial perfusion improves, coronary flow reserve may gain more widespread clinical use with perhaps as yet undiscovered therapeutic implications.

UR - http://www.scopus.com/inward/record.url?scp=0026040348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026040348&partnerID=8YFLogxK

U2 - 10.1016/0002-8703(91)90480-6

DO - 10.1016/0002-8703(91)90480-6

M3 - Article

C2 - 1833963

AN - SCOPUS:0026040348

VL - 122

SP - 1116

EP - 1128

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 4 PART 1

ER -