Correlates of cognitive function in middle-aged adults

James R. Cerhan, Aaron R. Folsom, James A. Mortimer, Eyal Shahar, David S. Knopman, Paul G. McGovern, Melissa A. Hays, Larry D. Crum, Gerardo Heiss

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

The Atherosclerosis Risk in Communities Study administered cognitive function tests to more than 14,000 middle-aged adults in 1990-1992. The battery included the Delayed Word Recall test, the Digit Symbol Subtest of the Wechsler Adult Intelligence Scale-Revised, and the Controlled Oral Word Association (Word Fluency) test. Test performance was correlated positively with education level, negatively with age, was better in women than in men, and better in managers/professionals compared with other occupations. After controlling for these factors, race and community, the findings most consistent for both sexes were that Delayed Word Recall was negatively associated with depressive symptoms, diabetes, and fibrinogen level; the Digit Symbol Subtest was associated with marital status, negatively associated with depressive symptoms, smoking status, fibrinogen level, and carotid intima-media thickness, and positively associated with alcohol drinking and FEV1; and the Word Fluency test was positively associated with marital status, alcohol drinking, sports participation, and FEV1. Most of these cross-sectional results were in the predicted direction and have biologic plausibility, but mean differences between extreme categories were small (generally on the order of 0.1 to 0.2 of a standard deviation). Longitudinal study is warranted to evaluate whether small differences in middle-age lead to larger, clinically meaningful deficits with aging.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalGerontology
Volume44
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Marital Status
Alcohol Drinking
Fibrinogen
Cognition
Word Association Tests
Depression
Carotid Intima-Media Thickness
Intelligence
Occupations
Sports
Longitudinal Studies
Atherosclerosis
Smoking
Education
Direction compound

Keywords

  • Cognition
  • Cognitive disorders
  • Dementia
  • Risk factors

ASJC Scopus subject areas

  • Aging

Cite this

Cerhan, J. R., Folsom, A. R., Mortimer, J. A., Shahar, E., Knopman, D. S., McGovern, P. G., ... Heiss, G. (1998). Correlates of cognitive function in middle-aged adults. Gerontology, 44(2), 95-105. https://doi.org/10.1159/000021991

Correlates of cognitive function in middle-aged adults. / Cerhan, James R.; Folsom, Aaron R.; Mortimer, James A.; Shahar, Eyal; Knopman, David S.; McGovern, Paul G.; Hays, Melissa A.; Crum, Larry D.; Heiss, Gerardo.

In: Gerontology, Vol. 44, No. 2, 1998, p. 95-105.

Research output: Contribution to journalArticle

Cerhan, JR, Folsom, AR, Mortimer, JA, Shahar, E, Knopman, DS, McGovern, PG, Hays, MA, Crum, LD & Heiss, G 1998, 'Correlates of cognitive function in middle-aged adults', Gerontology, vol. 44, no. 2, pp. 95-105. https://doi.org/10.1159/000021991
Cerhan JR, Folsom AR, Mortimer JA, Shahar E, Knopman DS, McGovern PG et al. Correlates of cognitive function in middle-aged adults. Gerontology. 1998;44(2):95-105. https://doi.org/10.1159/000021991
Cerhan, James R. ; Folsom, Aaron R. ; Mortimer, James A. ; Shahar, Eyal ; Knopman, David S. ; McGovern, Paul G. ; Hays, Melissa A. ; Crum, Larry D. ; Heiss, Gerardo. / Correlates of cognitive function in middle-aged adults. In: Gerontology. 1998 ; Vol. 44, No. 2. pp. 95-105.
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