Correlation and prediction of mass transport across membranes II: Influence of vehicle polarity on flux from solutions and suspensions

Samuel H. Yalkowsky, Gordon L. Flynn

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The effects of systematic alteration of vehicle composition on the release rate of drugs from their vehicle were studied. Equations were developed which quantitatively predict the rate of transport of a drug across a membrane separating two identical binary aqueous solvents. Separate equations were derived for solutions and for suspensions, which account for both the resistance of the membrane and the resistance of the solvent to drug diffusion.

Original languageEnglish (US)
Pages (from-to)1276-1280
Number of pages5
JournalJournal of pharmaceutical sciences
Volume63
Issue number8
DOIs
StatePublished - Aug 1974
Externally publishedYes

Keywords

  • Drug release rates‐effects of systematic alteration of vehicle composition, solutions and suspensions, equations
  • Membrane diffusion‐effect of vehicle polarity on flux from solutions and suspensions, systematic alteration of vehicle composition, equations
  • Vehicle polarity‐effect of systematic alteration of vehicle composition on release rates of drugs, equations

ASJC Scopus subject areas

  • Pharmaceutical Science

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