Correlation between measured creatinine clearance and calculated creatinine clearance in ovarian cancer patients

Joseph T. Chambers, Setsuko K. Chambers, Peter E. Schwartz

Research output: Contribution to journalArticle

21 Scopus citations


In 84 patients with advanced ovarian cancer, the measured 24-hr urinary creatinine clearance and a calculated Creatinine clearance were compared prior to as-platinum-based chemotherapy. The overall correlation between the two methods was excellent, using Pearson's coefficient of correlation test, r = 0.508 and P < 0.000001. In a subset of 59 patients with adequate 24-hr urine collections, analysis showed a correlation of r = 0.526 and P = 0.000018. Furthermore, in this group of patients using a creatinine clearance of 45 ml/min as a threshold for dose adjustment, there was only a 3.3% error in accepting the calculated creatinine clearance for the measured creatinine clearance. In summary, in patients with advanced ovarian cancer, even in the postoperative state, an evaluation of renal function with a calculated creatinine clearance prior to chemotherapy is sufficient.

Original languageEnglish (US)
Pages (from-to)66-68
Number of pages3
JournalGynecologic oncology
Issue number1
StatePublished - Jan 1990
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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