Correlation between the effects of polyamine analogues on DNA conformation and cell growth

H. S. Basu, B. G. Feuerstein, D. F. Deen, W. P. Lubich, Burt G.F. Feuerstein, K. Samejima, L. J. Marton

Research output: Contribution to journalArticle

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Abstract

Effects of a number of synthetic analogues of the natural polyamines on the B-Z transition of poly(dG-me5dC) and on the aggregation of calf thymus DNA in solution were studied using circular dichroic and UV spectroscopy. The efficiency of induction of the B-Z transition decreased with a decrease in the length of the central alkyl chain of the analogues, and the ability of analogues to aggregate DNA was markedly reduced for compounds ethylated at the terminal amines. Both structural variations appear to have important effects on the biological functions of polyamines. Most analogues studied depleted intracellular levels of natural polyamines, but only those that did not readily induce the B-Z transition and/or aggregate DNA were good inhibitors of cell growth. All but one of the analogues studied were able to rescue cell - at least in part - from the growth-inhibitory effects of α-difluoromethylornithine. The single analogue that was unable to effect rescue also failed to induce both the B-Z transition and the aggregation of DNA.

Original languageEnglish (US)
Pages (from-to)5591-5597
Number of pages7
JournalCancer Research
Volume49
Issue number20
StatePublished - 1989
Externally publishedYes

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Nucleic Acid Conformation
Polyamines
DNA
Growth
Eflornithine
Growth Inhibitors
Amines
Spectrum Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Basu, H. S., Feuerstein, B. G., Deen, D. F., Lubich, W. P., Feuerstein, B. G. F., Samejima, K., & Marton, L. J. (1989). Correlation between the effects of polyamine analogues on DNA conformation and cell growth. Cancer Research, 49(20), 5591-5597.

Correlation between the effects of polyamine analogues on DNA conformation and cell growth. / Basu, H. S.; Feuerstein, B. G.; Deen, D. F.; Lubich, W. P.; Feuerstein, Burt G.F.; Samejima, K.; Marton, L. J.

In: Cancer Research, Vol. 49, No. 20, 1989, p. 5591-5597.

Research output: Contribution to journalArticle

Basu, HS, Feuerstein, BG, Deen, DF, Lubich, WP, Feuerstein, BGF, Samejima, K & Marton, LJ 1989, 'Correlation between the effects of polyamine analogues on DNA conformation and cell growth', Cancer Research, vol. 49, no. 20, pp. 5591-5597.
Basu HS, Feuerstein BG, Deen DF, Lubich WP, Feuerstein BGF, Samejima K et al. Correlation between the effects of polyamine analogues on DNA conformation and cell growth. Cancer Research. 1989;49(20):5591-5597.
Basu, H. S. ; Feuerstein, B. G. ; Deen, D. F. ; Lubich, W. P. ; Feuerstein, Burt G.F. ; Samejima, K. ; Marton, L. J. / Correlation between the effects of polyamine analogues on DNA conformation and cell growth. In: Cancer Research. 1989 ; Vol. 49, No. 20. pp. 5591-5597.
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AU - Samejima, K.

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