Correlation functions for lipid membrane dynamics obtained from NMR spectroscopy

Alexander A. Nevzorov, Theodore "Ted" Trouard, Michael F Brown

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Abstract

Nuclear magnetic resonance (NMR) studies of the spin relaxation of lipid membranes provide a powerful tool for investigating the dynamics of these important biological structural elements. Here spectral densities of motion for various dynamical models have been fitted to 2H spin-lattice relaxation rates (R1Z) measured for vesicles for 1,2-dimyristoyl-sn-glycero-3-phosphocholine, in the liquid-crystalline state, over a broad frequency range (2.50-95.3 MHz; total of 15 magnetic-field strengths). Moreover, the corresponding 13C R1Z values predicted from the models have been compared to experiment from 15.0 to 151 MHz, thereby enabling unification of the NMR relaxation data for bilayer lipids. A molecular diffusion model or alternatively a three-dimensional collective fluctuation model describes best the 2H and 13C R1Z data. To emphasize the universality of this approach, the models have also been fitted to 13C R1Z data for vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (15.0-151 MHz; eight magnetic field strengths), and the 2H R1Z values for the corresponding multilamellar dispersions theoretically predicted. Correlation functions have been calculated for the lipid reorientations from the analysis of NMR relaxation data. The results suggest that slower motions are predominant in the low to mid megahertz range due to noncollective molecular motions or thermal collective excitations, whereas the bilayer interior corresponds to liquid hydrocarbon. The reorientational correlation functions derived from NMR spectroscopy are compared to recent molecular-dynamics simulations of bilayer lipids in the fluid phase.

Original languageEnglish (US)
Pages (from-to)3276-3282
Number of pages7
JournalPhysical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
Volume55
Issue number3 SUPPL. B
StatePublished - Mar 1997

Fingerprint

Nuclear Magnetic Resonance
magnetic resonance spectroscopy
Lipids
lipids
Correlation Function
Spectroscopy
Membrane
membranes
Lipid Bilayer
nuclear magnetic resonance
Vesicles
Motion
Magnetic Field
Liquid
field strength
Spectral Density
Diffusion Model
Dynamical Model
Hydrocarbons
Unification

ASJC Scopus subject areas

  • Mathematical Physics
  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics

Cite this

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title = "Correlation functions for lipid membrane dynamics obtained from NMR spectroscopy",
abstract = "Nuclear magnetic resonance (NMR) studies of the spin relaxation of lipid membranes provide a powerful tool for investigating the dynamics of these important biological structural elements. Here spectral densities of motion for various dynamical models have been fitted to 2H spin-lattice relaxation rates (R1Z) measured for vesicles for 1,2-dimyristoyl-sn-glycero-3-phosphocholine, in the liquid-crystalline state, over a broad frequency range (2.50-95.3 MHz; total of 15 magnetic-field strengths). Moreover, the corresponding 13C R1Z values predicted from the models have been compared to experiment from 15.0 to 151 MHz, thereby enabling unification of the NMR relaxation data for bilayer lipids. A molecular diffusion model or alternatively a three-dimensional collective fluctuation model describes best the 2H and 13C R1Z data. To emphasize the universality of this approach, the models have also been fitted to 13C R1Z data for vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (15.0-151 MHz; eight magnetic field strengths), and the 2H R1Z values for the corresponding multilamellar dispersions theoretically predicted. Correlation functions have been calculated for the lipid reorientations from the analysis of NMR relaxation data. The results suggest that slower motions are predominant in the low to mid megahertz range due to noncollective molecular motions or thermal collective excitations, whereas the bilayer interior corresponds to liquid hydrocarbon. The reorientational correlation functions derived from NMR spectroscopy are compared to recent molecular-dynamics simulations of bilayer lipids in the fluid phase.",
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T1 - Correlation functions for lipid membrane dynamics obtained from NMR spectroscopy

AU - Nevzorov, Alexander A.

AU - Trouard, Theodore "Ted"

AU - Brown, Michael F

PY - 1997/3

Y1 - 1997/3

N2 - Nuclear magnetic resonance (NMR) studies of the spin relaxation of lipid membranes provide a powerful tool for investigating the dynamics of these important biological structural elements. Here spectral densities of motion for various dynamical models have been fitted to 2H spin-lattice relaxation rates (R1Z) measured for vesicles for 1,2-dimyristoyl-sn-glycero-3-phosphocholine, in the liquid-crystalline state, over a broad frequency range (2.50-95.3 MHz; total of 15 magnetic-field strengths). Moreover, the corresponding 13C R1Z values predicted from the models have been compared to experiment from 15.0 to 151 MHz, thereby enabling unification of the NMR relaxation data for bilayer lipids. A molecular diffusion model or alternatively a three-dimensional collective fluctuation model describes best the 2H and 13C R1Z data. To emphasize the universality of this approach, the models have also been fitted to 13C R1Z data for vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (15.0-151 MHz; eight magnetic field strengths), and the 2H R1Z values for the corresponding multilamellar dispersions theoretically predicted. Correlation functions have been calculated for the lipid reorientations from the analysis of NMR relaxation data. The results suggest that slower motions are predominant in the low to mid megahertz range due to noncollective molecular motions or thermal collective excitations, whereas the bilayer interior corresponds to liquid hydrocarbon. The reorientational correlation functions derived from NMR spectroscopy are compared to recent molecular-dynamics simulations of bilayer lipids in the fluid phase.

AB - Nuclear magnetic resonance (NMR) studies of the spin relaxation of lipid membranes provide a powerful tool for investigating the dynamics of these important biological structural elements. Here spectral densities of motion for various dynamical models have been fitted to 2H spin-lattice relaxation rates (R1Z) measured for vesicles for 1,2-dimyristoyl-sn-glycero-3-phosphocholine, in the liquid-crystalline state, over a broad frequency range (2.50-95.3 MHz; total of 15 magnetic-field strengths). Moreover, the corresponding 13C R1Z values predicted from the models have been compared to experiment from 15.0 to 151 MHz, thereby enabling unification of the NMR relaxation data for bilayer lipids. A molecular diffusion model or alternatively a three-dimensional collective fluctuation model describes best the 2H and 13C R1Z data. To emphasize the universality of this approach, the models have also been fitted to 13C R1Z data for vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (15.0-151 MHz; eight magnetic field strengths), and the 2H R1Z values for the corresponding multilamellar dispersions theoretically predicted. Correlation functions have been calculated for the lipid reorientations from the analysis of NMR relaxation data. The results suggest that slower motions are predominant in the low to mid megahertz range due to noncollective molecular motions or thermal collective excitations, whereas the bilayer interior corresponds to liquid hydrocarbon. The reorientational correlation functions derived from NMR spectroscopy are compared to recent molecular-dynamics simulations of bilayer lipids in the fluid phase.

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