Correlation of electrocorticographic to clinical seizure onset and interhemispheric propagation times in temporal lobe epilepsy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study was performed to test the hypothesis that, in human temporal lobe epilepsy, electrocorticographic time factors involved in the ictal EEG to clinical ictal transition (electrocorticographic to clinical seizure onset time, ECOT) and the interhemispheric propagation of epileptic activity (interhemispheric propagation time, IHPT), which are independently correlated with temporal lobe epileptogenicity and predictive of seizure-free outcome following temporal lobectomy, are correlated with one another in a quantitative fashion. A series of 37 patients with medically intractable temporal lobe seizures was studied with long-term subdural videoelectroencephalographic monitoring. Temporal lobe seizure interhemispheric propagation time (IHPT) was found to be a negative, exponential function of electrocorticographic to clinical seizure onset time (ECOT) (f(x) = 8.201 × 10-0.016x, r = 0.347, d.f. = 35, t = 2.19, p < 0.05, where f(x) = IHPT and x = ECOT). A small increase in ECOT was associated with a substantial decrease in IHPT and vice versa. The results suggest the electrophysiological time factor, ECOT, involved in the transition from ictal EEG seizure onset to clinical seizure onset, may determine the speed of interhemispheric propagation of established epileptic activity. The results suggest the interesting hypothesis that, in human temporal lobe epilepsy and, perhaps, under non-pathological circumstances, the human temporal lobe might possess a "time-labeling" function amenable to quantitative analysis.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalPathophysiology
Volume13
Issue number4
DOIs
StatePublished - Dec 2006

Fingerprint

Temporal Lobe Epilepsy
Seizures
Temporal Lobe
Stroke
Electroencephalography

Keywords

  • Temporal lobe epilepsy
  • Time factors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

@article{bc4cbf1c4a964c58824f366ac67908d1,
title = "Correlation of electrocorticographic to clinical seizure onset and interhemispheric propagation times in temporal lobe epilepsy",
abstract = "This study was performed to test the hypothesis that, in human temporal lobe epilepsy, electrocorticographic time factors involved in the ictal EEG to clinical ictal transition (electrocorticographic to clinical seizure onset time, ECOT) and the interhemispheric propagation of epileptic activity (interhemispheric propagation time, IHPT), which are independently correlated with temporal lobe epileptogenicity and predictive of seizure-free outcome following temporal lobectomy, are correlated with one another in a quantitative fashion. A series of 37 patients with medically intractable temporal lobe seizures was studied with long-term subdural videoelectroencephalographic monitoring. Temporal lobe seizure interhemispheric propagation time (IHPT) was found to be a negative, exponential function of electrocorticographic to clinical seizure onset time (ECOT) (f(x) = 8.201 × 10-0.016x, r = 0.347, d.f. = 35, t = 2.19, p < 0.05, where f(x) = IHPT and x = ECOT). A small increase in ECOT was associated with a substantial decrease in IHPT and vice versa. The results suggest the electrophysiological time factor, ECOT, involved in the transition from ictal EEG seizure onset to clinical seizure onset, may determine the speed of interhemispheric propagation of established epileptic activity. The results suggest the interesting hypothesis that, in human temporal lobe epilepsy and, perhaps, under non-pathological circumstances, the human temporal lobe might possess a {"}time-labeling{"} function amenable to quantitative analysis.",
keywords = "Temporal lobe epilepsy, Time factors",
author = "Weinand, {Martin E} and Namath Hussain and Labiner, {David M} and Ahern, {Geoffrey L}",
year = "2006",
month = "12",
doi = "10.1016/j.pathophys.2006.08.002",
language = "English (US)",
volume = "13",
pages = "233--236",
journal = "Pathophysiology",
issn = "0928-4680",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Correlation of electrocorticographic to clinical seizure onset and interhemispheric propagation times in temporal lobe epilepsy

AU - Weinand, Martin E

AU - Hussain, Namath

AU - Labiner, David M

AU - Ahern, Geoffrey L

PY - 2006/12

Y1 - 2006/12

N2 - This study was performed to test the hypothesis that, in human temporal lobe epilepsy, electrocorticographic time factors involved in the ictal EEG to clinical ictal transition (electrocorticographic to clinical seizure onset time, ECOT) and the interhemispheric propagation of epileptic activity (interhemispheric propagation time, IHPT), which are independently correlated with temporal lobe epileptogenicity and predictive of seizure-free outcome following temporal lobectomy, are correlated with one another in a quantitative fashion. A series of 37 patients with medically intractable temporal lobe seizures was studied with long-term subdural videoelectroencephalographic monitoring. Temporal lobe seizure interhemispheric propagation time (IHPT) was found to be a negative, exponential function of electrocorticographic to clinical seizure onset time (ECOT) (f(x) = 8.201 × 10-0.016x, r = 0.347, d.f. = 35, t = 2.19, p < 0.05, where f(x) = IHPT and x = ECOT). A small increase in ECOT was associated with a substantial decrease in IHPT and vice versa. The results suggest the electrophysiological time factor, ECOT, involved in the transition from ictal EEG seizure onset to clinical seizure onset, may determine the speed of interhemispheric propagation of established epileptic activity. The results suggest the interesting hypothesis that, in human temporal lobe epilepsy and, perhaps, under non-pathological circumstances, the human temporal lobe might possess a "time-labeling" function amenable to quantitative analysis.

AB - This study was performed to test the hypothesis that, in human temporal lobe epilepsy, electrocorticographic time factors involved in the ictal EEG to clinical ictal transition (electrocorticographic to clinical seizure onset time, ECOT) and the interhemispheric propagation of epileptic activity (interhemispheric propagation time, IHPT), which are independently correlated with temporal lobe epileptogenicity and predictive of seizure-free outcome following temporal lobectomy, are correlated with one another in a quantitative fashion. A series of 37 patients with medically intractable temporal lobe seizures was studied with long-term subdural videoelectroencephalographic monitoring. Temporal lobe seizure interhemispheric propagation time (IHPT) was found to be a negative, exponential function of electrocorticographic to clinical seizure onset time (ECOT) (f(x) = 8.201 × 10-0.016x, r = 0.347, d.f. = 35, t = 2.19, p < 0.05, where f(x) = IHPT and x = ECOT). A small increase in ECOT was associated with a substantial decrease in IHPT and vice versa. The results suggest the electrophysiological time factor, ECOT, involved in the transition from ictal EEG seizure onset to clinical seizure onset, may determine the speed of interhemispheric propagation of established epileptic activity. The results suggest the interesting hypothesis that, in human temporal lobe epilepsy and, perhaps, under non-pathological circumstances, the human temporal lobe might possess a "time-labeling" function amenable to quantitative analysis.

KW - Temporal lobe epilepsy

KW - Time factors

UR - http://www.scopus.com/inward/record.url?scp=33750147227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750147227&partnerID=8YFLogxK

U2 - 10.1016/j.pathophys.2006.08.002

DO - 10.1016/j.pathophys.2006.08.002

M3 - Article

C2 - 16963240

AN - SCOPUS:33750147227

VL - 13

SP - 233

EP - 236

JO - Pathophysiology

JF - Pathophysiology

SN - 0928-4680

IS - 4

ER -