Correlation of oesophageal acid exposure with Barrett's oesophagus length

R. Fass, R. W. Hell, H. S. Garewal, P. Martinez, G. Pulliam, Christopher S Wendel, R. E. Sampliner

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Background - Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. Aims - To determine if there is a correlation between oesophageal acid exposure and the length of Barrett's mucosa. We also compared the extent of oesophageal acid exposure between patients with short segment (SSBE) and long segment (LSBE) Barrett's oesophagus. Methods - Twenty seven patients with Barrett's oesophagus were recruited prospectively into the study from the outpatient gastroenterology clinic at the Southern Arizona VA Health Care System. Diagnosis of Barrett's oesophagus and its anatomical characteristics were determined during upper endoscopy. Ambulatory 24 hour oesophageal pH monitoring assessed the extent of oesophageal acid exposure. Results - There was a significant correlation between per cent total time pH less than 4 and length of Barrett's mucosa (r=0.6234, p=0.0005). In addition, there was a significant correlation between per cent upright and supine time pH less than 4 and length of Barrett's mucosa (r=0.5847, p=0.0014 and r=0.6265 p=0.0006, respectively). Patients with SSBE had significantly less oesophageal acid exposure than patients with LSBE, in terms of both per cent total time and per cent supine time pH less than 4 (p<0.05). Conclusions - The length of Barrett's mucosa correlated with the duration of oesophageal acid exposure. Patients with LSBE experienced significantly more oesophageal acid exposure than patients with SSBE. Duration of oesophageal acid exposure appears to be an important contributing factor in determining the length of Barrett's mucosa.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalGut
Volume48
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Barrett Esophagus
Mucous Membrane
Acids
Esophageal Diseases
Esophageal pH Monitoring
Gastroenterology
Gastroesophageal Reflux
Ambulatory Care Facilities
Endoscopy
Delivery of Health Care

Keywords

  • Barrett's oesophagus
  • Intestinal metaplasia
  • Oesophageal acid exposure
  • Oesophageal pH monitoring

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Fass, R., Hell, R. W., Garewal, H. S., Martinez, P., Pulliam, G., Wendel, C. S., & Sampliner, R. E. (2001). Correlation of oesophageal acid exposure with Barrett's oesophagus length. Gut, 48(3), 310-313. https://doi.org/10.1136/gut.48.3.310

Correlation of oesophageal acid exposure with Barrett's oesophagus length. / Fass, R.; Hell, R. W.; Garewal, H. S.; Martinez, P.; Pulliam, G.; Wendel, Christopher S; Sampliner, R. E.

In: Gut, Vol. 48, No. 3, 2001, p. 310-313.

Research output: Contribution to journalArticle

Fass, R, Hell, RW, Garewal, HS, Martinez, P, Pulliam, G, Wendel, CS & Sampliner, RE 2001, 'Correlation of oesophageal acid exposure with Barrett's oesophagus length', Gut, vol. 48, no. 3, pp. 310-313. https://doi.org/10.1136/gut.48.3.310
Fass R, Hell RW, Garewal HS, Martinez P, Pulliam G, Wendel CS et al. Correlation of oesophageal acid exposure with Barrett's oesophagus length. Gut. 2001;48(3):310-313. https://doi.org/10.1136/gut.48.3.310
Fass, R. ; Hell, R. W. ; Garewal, H. S. ; Martinez, P. ; Pulliam, G. ; Wendel, Christopher S ; Sampliner, R. E. / Correlation of oesophageal acid exposure with Barrett's oesophagus length. In: Gut. 2001 ; Vol. 48, No. 3. pp. 310-313.
@article{be8960c2f6be4ec6854939459df4f3aa,
title = "Correlation of oesophageal acid exposure with Barrett's oesophagus length",
abstract = "Background - Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. Aims - To determine if there is a correlation between oesophageal acid exposure and the length of Barrett's mucosa. We also compared the extent of oesophageal acid exposure between patients with short segment (SSBE) and long segment (LSBE) Barrett's oesophagus. Methods - Twenty seven patients with Barrett's oesophagus were recruited prospectively into the study from the outpatient gastroenterology clinic at the Southern Arizona VA Health Care System. Diagnosis of Barrett's oesophagus and its anatomical characteristics were determined during upper endoscopy. Ambulatory 24 hour oesophageal pH monitoring assessed the extent of oesophageal acid exposure. Results - There was a significant correlation between per cent total time pH less than 4 and length of Barrett's mucosa (r=0.6234, p=0.0005). In addition, there was a significant correlation between per cent upright and supine time pH less than 4 and length of Barrett's mucosa (r=0.5847, p=0.0014 and r=0.6265 p=0.0006, respectively). Patients with SSBE had significantly less oesophageal acid exposure than patients with LSBE, in terms of both per cent total time and per cent supine time pH less than 4 (p<0.05). Conclusions - The length of Barrett's mucosa correlated with the duration of oesophageal acid exposure. Patients with LSBE experienced significantly more oesophageal acid exposure than patients with SSBE. Duration of oesophageal acid exposure appears to be an important contributing factor in determining the length of Barrett's mucosa.",
keywords = "Barrett's oesophagus, Intestinal metaplasia, Oesophageal acid exposure, Oesophageal pH monitoring",
author = "R. Fass and Hell, {R. W.} and Garewal, {H. S.} and P. Martinez and G. Pulliam and Wendel, {Christopher S} and Sampliner, {R. E.}",
year = "2001",
doi = "10.1136/gut.48.3.310",
language = "English (US)",
volume = "48",
pages = "310--313",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "3",

}

TY - JOUR

T1 - Correlation of oesophageal acid exposure with Barrett's oesophagus length

AU - Fass, R.

AU - Hell, R. W.

AU - Garewal, H. S.

AU - Martinez, P.

AU - Pulliam, G.

AU - Wendel, Christopher S

AU - Sampliner, R. E.

PY - 2001

Y1 - 2001

N2 - Background - Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. Aims - To determine if there is a correlation between oesophageal acid exposure and the length of Barrett's mucosa. We also compared the extent of oesophageal acid exposure between patients with short segment (SSBE) and long segment (LSBE) Barrett's oesophagus. Methods - Twenty seven patients with Barrett's oesophagus were recruited prospectively into the study from the outpatient gastroenterology clinic at the Southern Arizona VA Health Care System. Diagnosis of Barrett's oesophagus and its anatomical characteristics were determined during upper endoscopy. Ambulatory 24 hour oesophageal pH monitoring assessed the extent of oesophageal acid exposure. Results - There was a significant correlation between per cent total time pH less than 4 and length of Barrett's mucosa (r=0.6234, p=0.0005). In addition, there was a significant correlation between per cent upright and supine time pH less than 4 and length of Barrett's mucosa (r=0.5847, p=0.0014 and r=0.6265 p=0.0006, respectively). Patients with SSBE had significantly less oesophageal acid exposure than patients with LSBE, in terms of both per cent total time and per cent supine time pH less than 4 (p<0.05). Conclusions - The length of Barrett's mucosa correlated with the duration of oesophageal acid exposure. Patients with LSBE experienced significantly more oesophageal acid exposure than patients with SSBE. Duration of oesophageal acid exposure appears to be an important contributing factor in determining the length of Barrett's mucosa.

AB - Background - Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. Aims - To determine if there is a correlation between oesophageal acid exposure and the length of Barrett's mucosa. We also compared the extent of oesophageal acid exposure between patients with short segment (SSBE) and long segment (LSBE) Barrett's oesophagus. Methods - Twenty seven patients with Barrett's oesophagus were recruited prospectively into the study from the outpatient gastroenterology clinic at the Southern Arizona VA Health Care System. Diagnosis of Barrett's oesophagus and its anatomical characteristics were determined during upper endoscopy. Ambulatory 24 hour oesophageal pH monitoring assessed the extent of oesophageal acid exposure. Results - There was a significant correlation between per cent total time pH less than 4 and length of Barrett's mucosa (r=0.6234, p=0.0005). In addition, there was a significant correlation between per cent upright and supine time pH less than 4 and length of Barrett's mucosa (r=0.5847, p=0.0014 and r=0.6265 p=0.0006, respectively). Patients with SSBE had significantly less oesophageal acid exposure than patients with LSBE, in terms of both per cent total time and per cent supine time pH less than 4 (p<0.05). Conclusions - The length of Barrett's mucosa correlated with the duration of oesophageal acid exposure. Patients with LSBE experienced significantly more oesophageal acid exposure than patients with SSBE. Duration of oesophageal acid exposure appears to be an important contributing factor in determining the length of Barrett's mucosa.

KW - Barrett's oesophagus

KW - Intestinal metaplasia

KW - Oesophageal acid exposure

KW - Oesophageal pH monitoring

UR - http://www.scopus.com/inward/record.url?scp=0035061032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035061032&partnerID=8YFLogxK

U2 - 10.1136/gut.48.3.310

DO - 10.1136/gut.48.3.310

M3 - Article

C2 - 11171818

AN - SCOPUS:0035061032

VL - 48

SP - 310

EP - 313

JO - Gut

JF - Gut

SN - 0017-5749

IS - 3

ER -