Cortical entrainment of human hypoglossal motor unit activities

Christopher M. Laine, Laura A. Nickerson, Elizabeth F Bailey

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Output from the primary motor cortex contains oscillations that can have frequency-specific effects on the firing of motoneurons (MNs). Whereas much is known about the effects of oscillatory cortical drive on the output of spinal MN pools, considerably less is known about the effects on cranial motor nuclei, which govern speech/oromotor control. Here, we investigated cortical input to one such motor pool, the hypoglossal motor nucleus (HMN), which controls muscles of the tongue. We recorded intramuscular genioglossus electromyogram (EMG) and scalp EEG from healthy adult subjects performing a tongue protrusion task. Cortical entrainment of HMN population activity was assessed by measuring coherence between EEG and multiunit EMG activity. In addition, cortical entrainment of individual MN firing activity was assessed by measuring phase locking between single motor unit (SMU) action potentials and EEG oscillations. We found that cortical entrainment of multiunit activity was detectable within the 15- to 40-Hz frequency range but was inconsistent across recordings. By comparison, cortical entrainment of SMU spike timing was reliable within the same frequency range. Furthermore, this effect was found to be intermittent over time. Our study represents an important step in understanding corticomuscular synchronization in the context of human oromotor control and is the first study to document SMU entrainment by cortical oscillations in vivo.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalJournal of Neurophysiology
Volume107
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Motor Neurons
Electroencephalography
Motor Activity
Electromyography
Tongue
Motor Cortex
Scalp
Action Potentials
Healthy Volunteers
Muscles
Population

Keywords

  • Corticomuscular coherence
  • Hypoglossal motor nucleus
  • Phase locking

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Cortical entrainment of human hypoglossal motor unit activities. / Laine, Christopher M.; Nickerson, Laura A.; Bailey, Elizabeth F.

In: Journal of Neurophysiology, Vol. 107, No. 1, 01.2012, p. 493-499.

Research output: Contribution to journalArticle

Laine, Christopher M. ; Nickerson, Laura A. ; Bailey, Elizabeth F. / Cortical entrainment of human hypoglossal motor unit activities. In: Journal of Neurophysiology. 2012 ; Vol. 107, No. 1. pp. 493-499.
@article{cf515bc7ab3d43bc82adc2d7c59316e3,
title = "Cortical entrainment of human hypoglossal motor unit activities",
abstract = "Output from the primary motor cortex contains oscillations that can have frequency-specific effects on the firing of motoneurons (MNs). Whereas much is known about the effects of oscillatory cortical drive on the output of spinal MN pools, considerably less is known about the effects on cranial motor nuclei, which govern speech/oromotor control. Here, we investigated cortical input to one such motor pool, the hypoglossal motor nucleus (HMN), which controls muscles of the tongue. We recorded intramuscular genioglossus electromyogram (EMG) and scalp EEG from healthy adult subjects performing a tongue protrusion task. Cortical entrainment of HMN population activity was assessed by measuring coherence between EEG and multiunit EMG activity. In addition, cortical entrainment of individual MN firing activity was assessed by measuring phase locking between single motor unit (SMU) action potentials and EEG oscillations. We found that cortical entrainment of multiunit activity was detectable within the 15- to 40-Hz frequency range but was inconsistent across recordings. By comparison, cortical entrainment of SMU spike timing was reliable within the same frequency range. Furthermore, this effect was found to be intermittent over time. Our study represents an important step in understanding corticomuscular synchronization in the context of human oromotor control and is the first study to document SMU entrainment by cortical oscillations in vivo.",
keywords = "Corticomuscular coherence, Hypoglossal motor nucleus, Phase locking",
author = "Laine, {Christopher M.} and Nickerson, {Laura A.} and Bailey, {Elizabeth F}",
year = "2012",
month = "1",
doi = "10.1152/jn.00769.2011",
language = "English (US)",
volume = "107",
pages = "493--499",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Cortical entrainment of human hypoglossal motor unit activities

AU - Laine, Christopher M.

AU - Nickerson, Laura A.

AU - Bailey, Elizabeth F

PY - 2012/1

Y1 - 2012/1

N2 - Output from the primary motor cortex contains oscillations that can have frequency-specific effects on the firing of motoneurons (MNs). Whereas much is known about the effects of oscillatory cortical drive on the output of spinal MN pools, considerably less is known about the effects on cranial motor nuclei, which govern speech/oromotor control. Here, we investigated cortical input to one such motor pool, the hypoglossal motor nucleus (HMN), which controls muscles of the tongue. We recorded intramuscular genioglossus electromyogram (EMG) and scalp EEG from healthy adult subjects performing a tongue protrusion task. Cortical entrainment of HMN population activity was assessed by measuring coherence between EEG and multiunit EMG activity. In addition, cortical entrainment of individual MN firing activity was assessed by measuring phase locking between single motor unit (SMU) action potentials and EEG oscillations. We found that cortical entrainment of multiunit activity was detectable within the 15- to 40-Hz frequency range but was inconsistent across recordings. By comparison, cortical entrainment of SMU spike timing was reliable within the same frequency range. Furthermore, this effect was found to be intermittent over time. Our study represents an important step in understanding corticomuscular synchronization in the context of human oromotor control and is the first study to document SMU entrainment by cortical oscillations in vivo.

AB - Output from the primary motor cortex contains oscillations that can have frequency-specific effects on the firing of motoneurons (MNs). Whereas much is known about the effects of oscillatory cortical drive on the output of spinal MN pools, considerably less is known about the effects on cranial motor nuclei, which govern speech/oromotor control. Here, we investigated cortical input to one such motor pool, the hypoglossal motor nucleus (HMN), which controls muscles of the tongue. We recorded intramuscular genioglossus electromyogram (EMG) and scalp EEG from healthy adult subjects performing a tongue protrusion task. Cortical entrainment of HMN population activity was assessed by measuring coherence between EEG and multiunit EMG activity. In addition, cortical entrainment of individual MN firing activity was assessed by measuring phase locking between single motor unit (SMU) action potentials and EEG oscillations. We found that cortical entrainment of multiunit activity was detectable within the 15- to 40-Hz frequency range but was inconsistent across recordings. By comparison, cortical entrainment of SMU spike timing was reliable within the same frequency range. Furthermore, this effect was found to be intermittent over time. Our study represents an important step in understanding corticomuscular synchronization in the context of human oromotor control and is the first study to document SMU entrainment by cortical oscillations in vivo.

KW - Corticomuscular coherence

KW - Hypoglossal motor nucleus

KW - Phase locking

UR - http://www.scopus.com/inward/record.url?scp=84255182462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255182462&partnerID=8YFLogxK

U2 - 10.1152/jn.00769.2011

DO - 10.1152/jn.00769.2011

M3 - Article

VL - 107

SP - 493

EP - 499

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 1

ER -