Cortical gene expression: prognostic value for seizure outcome following temporal lobectomy and amygdalohippocampectomy

Matthew J Gallek, Jesse Skoch, Tracy Ansay, Mandana Behbahani, David Mount, Ann Manziello, Marlys H Witte, Michael J Bernas, David M Labiner, Martin E Weinand

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Whole genome analyses were performed to test the hypothesis that temporal cortical gene expression differs between epilepsy patients rendered seizure-free versus non-seizure-free following anterior temporal lobectomy with amygdalohippocampectomy (ATL/AH). Twenty four patients underwent ATL/AH to treat medically intractable seizures of temporal lobe origin (mean age 35.5 years, mean follow-up 42.2 months); they were then dichotomized into seizure-free and non-seizure-free groups. Tissue RNA was isolated from the lateral temporal cortex and gene expression analysis was performed. Whole genome data were analyzed for prognostic value for seizure-free outcome following ATL/AH by logistic regression. Genes that could distinguish seizure outcome groups were identified based on providing an accuracy of >0.90 judging by area under the receiver operating characteristic curve, AUC, with a P value of the slope coefficient of

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalNeurogenetics
DOIs
StateAccepted/In press - Jun 2 2016

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Keywords

  • Amygdalohippocampectomy
  • Gene expression
  • Neurosurgical genomics
  • Prognostic factor
  • Temporal lobectomy

ASJC Scopus subject areas

  • Genetics(clinical)
  • Cellular and Molecular Neuroscience
  • Genetics

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