Cost-effectiveness of two new treatments for onychomycosis: An analysis of two comparative clinical trials

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Pharmacoeconomic analyses are becoming an increasingly integral component of the overall profile of new drugs. This is particularly true for terbinafine and itraconazole, because both agents have been shown to be clinically effective and relatively safe. Objective: This study examined the cost-effectiveness of terbinafine and itraconazole in two recent comparative clinical trials of these new agents for onychomycosis of the toenails. Methods: Data as reported in the two clinical trials were used as the basis for an analytic decision-tree model that included cost of drug, medical management of the disease and any adverse reactions, and clinical efficacy data into calculations that estimated the relative cost effectiveness ratio for each drug on the basis of cost per disease-free day. Results: The total cost of terbinafine therapy ranged from $697.55 to $699.11, and the total cost of itraconazole therapy ranged from $1216.40 to $1218.80. The expected cost per disease-free day of itraconazole was $2.05 and $2.37, in the Brautigam and De Backer trials, respectively; similar costs for terbinafine were $1.27 and $1.50. Relative to terbinafine, which was assigned a value of 1.0, the cost-effectiveness ratio of itraconazole was 1.62 and 1.58 in each trial, indicating a lower cost-effectiveness than terbinafine. Conclusion: Terbinafine is more cost-effective than itraconazole in the treatment of toenail onychomycosis.

Original languageEnglish (US)
JournalJournal of the American Academy of Dermatology
Volume38
Issue number5 III
StatePublished - 1998

Fingerprint

terbinafine
Onychomycosis
Itraconazole
Cost-Benefit Analysis
Clinical Trials
Costs and Cost Analysis
Cost of Illness
Nails
Pharmaceutical Economics
Decision Trees
Drug Costs
Disease Management
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{4fcaa173833d4d91a0d80234c47fef73,
title = "Cost-effectiveness of two new treatments for onychomycosis: An analysis of two comparative clinical trials",
abstract = "Background: Pharmacoeconomic analyses are becoming an increasingly integral component of the overall profile of new drugs. This is particularly true for terbinafine and itraconazole, because both agents have been shown to be clinically effective and relatively safe. Objective: This study examined the cost-effectiveness of terbinafine and itraconazole in two recent comparative clinical trials of these new agents for onychomycosis of the toenails. Methods: Data as reported in the two clinical trials were used as the basis for an analytic decision-tree model that included cost of drug, medical management of the disease and any adverse reactions, and clinical efficacy data into calculations that estimated the relative cost effectiveness ratio for each drug on the basis of cost per disease-free day. Results: The total cost of terbinafine therapy ranged from $697.55 to $699.11, and the total cost of itraconazole therapy ranged from $1216.40 to $1218.80. The expected cost per disease-free day of itraconazole was $2.05 and $2.37, in the Brautigam and De Backer trials, respectively; similar costs for terbinafine were $1.27 and $1.50. Relative to terbinafine, which was assigned a value of 1.0, the cost-effectiveness ratio of itraconazole was 1.62 and 1.58 in each trial, indicating a lower cost-effectiveness than terbinafine. Conclusion: Terbinafine is more cost-effective than itraconazole in the treatment of toenail onychomycosis.",
author = "Bootman, {J Lyle}",
year = "1998",
language = "English (US)",
volume = "38",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "5 III",

}

TY - JOUR

T1 - Cost-effectiveness of two new treatments for onychomycosis

T2 - An analysis of two comparative clinical trials

AU - Bootman, J Lyle

PY - 1998

Y1 - 1998

N2 - Background: Pharmacoeconomic analyses are becoming an increasingly integral component of the overall profile of new drugs. This is particularly true for terbinafine and itraconazole, because both agents have been shown to be clinically effective and relatively safe. Objective: This study examined the cost-effectiveness of terbinafine and itraconazole in two recent comparative clinical trials of these new agents for onychomycosis of the toenails. Methods: Data as reported in the two clinical trials were used as the basis for an analytic decision-tree model that included cost of drug, medical management of the disease and any adverse reactions, and clinical efficacy data into calculations that estimated the relative cost effectiveness ratio for each drug on the basis of cost per disease-free day. Results: The total cost of terbinafine therapy ranged from $697.55 to $699.11, and the total cost of itraconazole therapy ranged from $1216.40 to $1218.80. The expected cost per disease-free day of itraconazole was $2.05 and $2.37, in the Brautigam and De Backer trials, respectively; similar costs for terbinafine were $1.27 and $1.50. Relative to terbinafine, which was assigned a value of 1.0, the cost-effectiveness ratio of itraconazole was 1.62 and 1.58 in each trial, indicating a lower cost-effectiveness than terbinafine. Conclusion: Terbinafine is more cost-effective than itraconazole in the treatment of toenail onychomycosis.

AB - Background: Pharmacoeconomic analyses are becoming an increasingly integral component of the overall profile of new drugs. This is particularly true for terbinafine and itraconazole, because both agents have been shown to be clinically effective and relatively safe. Objective: This study examined the cost-effectiveness of terbinafine and itraconazole in two recent comparative clinical trials of these new agents for onychomycosis of the toenails. Methods: Data as reported in the two clinical trials were used as the basis for an analytic decision-tree model that included cost of drug, medical management of the disease and any adverse reactions, and clinical efficacy data into calculations that estimated the relative cost effectiveness ratio for each drug on the basis of cost per disease-free day. Results: The total cost of terbinafine therapy ranged from $697.55 to $699.11, and the total cost of itraconazole therapy ranged from $1216.40 to $1218.80. The expected cost per disease-free day of itraconazole was $2.05 and $2.37, in the Brautigam and De Backer trials, respectively; similar costs for terbinafine were $1.27 and $1.50. Relative to terbinafine, which was assigned a value of 1.0, the cost-effectiveness ratio of itraconazole was 1.62 and 1.58 in each trial, indicating a lower cost-effectiveness than terbinafine. Conclusion: Terbinafine is more cost-effective than itraconazole in the treatment of toenail onychomycosis.

UR - http://www.scopus.com/inward/record.url?scp=0031901997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031901997&partnerID=8YFLogxK

M3 - Article

C2 - 9594941

AN - SCOPUS:0031901997

VL - 38

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 5 III

ER -