Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes

Michael L. Cunningham, A. Jay Gandolfi, Klaus Brendel, I. Glenn Sipes

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Rat liver hepatocytes were used to bioactivate the aliphatic halides-carbon tetrachloride, trichloroethylene, and methylene chloride. Optimum bioactivation occured under a nitrogen atmosphere for carbon tetrachloride and under an oxygen atmosphere for trichloroethylene and methylene chloride. All were found to alkylate lipid and protein, while only carbon tetrachloride and trichloroethylene alkylated DNA and RNA.

Original languageEnglish (US)
Pages (from-to)1207-1212
Number of pages6
JournalLife Sciences
Volume29
Issue number12
DOIs
StatePublished - Sep 21 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes'. Together they form a unique fingerprint.

  • Cite this