Rat liver hepatocytes were used to bioactivate the aliphatic halides-carbon tetrachloride, trichloroethylene, and methylene chloride. Optimum bioactivation occured under a nitrogen atmosphere for carbon tetrachloride and under an oxygen atmosphere for trichloroethylene and methylene chloride. All were found to alkylate lipid and protein, while only carbon tetrachloride and trichloroethylene alkylated DNA and RNA.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)