Covarion structure in plastid genome evolution: A new statistical test

Cécile Ané, J. Gordon Burleigh, Michelle M Mcmahon, Michael Sanderson

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Covarion models of molecular evolution allow the rate of evolution of a site to vary through time. There are few simple and effective tests for covarion evolution, and consequently, little is known about the presence of covarion processes in molecular evolution. We describe two new tests for covarion evolution and demonstrate with simulations that they perform well under a wide range of conditions. A survey of covarion evolution in sequenced plastid genomes found evidence of covarion drift in at least 26 out of 57 genes. Covarion evolution is most evident in first and second codon positions of the plastid genes, and there is no evidence of covarion evolution in third codon positions. Therefore, the significant covarion tests are likely due to changes in the selective constraints of amino acids. The frequency of covarion evolution within the plastid genome suggests that covarion processes of evolution were important in generating the observed patterns of sequence variation among plastid genomes.

Original languageEnglish (US)
Pages (from-to)914-924
Number of pages11
JournalMolecular Biology and Evolution
Volume22
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Plastid Genomes
Statistical tests
plastid
statistical analysis
Molecular Evolution
genome
Genes
Codon
Plastids
Gene Order
Amino Acids
codons
test
plastid genome
molecular models
gene
testing
plastids
genes
amino acid

Keywords

  • Covarion
  • Model testing
  • Parametric bootstrap
  • Plastid genome evolution

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

Covarion structure in plastid genome evolution : A new statistical test. / Ané, Cécile; Burleigh, J. Gordon; Mcmahon, Michelle M; Sanderson, Michael.

In: Molecular Biology and Evolution, Vol. 22, No. 4, 04.2005, p. 914-924.

Research output: Contribution to journalArticle

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