CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion

David A. Spiegel, Jón T. Njardarson, John L. Wood

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Described is a rhodium carbenoid C-H insertion strategy for the construction of an isotwistane ring system needed for a late-stage fragmentation en route to the total synthesis of CP-263,114.

Original languageEnglish (US)
Pages (from-to)6545-6554
Number of pages10
JournalTetrahedron
Volume58
Issue number32
DOIs
StatePublished - Aug 5 2002
Externally publishedYes

Keywords

  • C-H insertion
  • CP-263,114
  • Diazo
  • Isotwistane
  • Phomoidrides
  • Rhodium carbenoid
  • β-ketoester

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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