Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy

Kotaro Fujimaki; Guang Yao

doi:10.1080/23723556.2017.1403531

Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy

Kotaro Fujimaki, Guang Yao

Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.

Original language	English (US)
Article number	e1403531
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2017.1403531
State	Published - Jan 2 2018

Keywords

Rb-E2F pathway
cell cycle entry
cellular quiescence
quiescence depth

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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abstract = "The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.",

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author = "Kotaro Fujimaki and Guang Yao",

note = "Funding Information: We apologize to colleagues whose work could not be cited due to space limitations. This work was supported by grants from the NSF (DMS-1463137 and DMS-1418172) and DARPA (WF911NF-14-1-0395).",

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