Abstract
The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
Original language | English (US) |
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Article number | e1403531 |
Journal | Molecular and Cellular Oncology |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 2018 |
Keywords
- Rb-E2F pathway
- cell cycle entry
- cellular quiescence
- quiescence depth
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research