Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy

Kotaro Fujimaki, Guang Yao

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.

Original languageEnglish (US)
Article numbere1403531
JournalMolecular and Cellular Oncology
Volume5
Issue number1
DOIs
StatePublished - Jan 2 2018

Keywords

  • Rb-E2F pathway
  • cell cycle entry
  • cellular quiescence
  • quiescence depth

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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