Abstract
The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
| Original language | English (US) |
|---|---|
| Article number | e1403531 |
| Journal | Molecular and Cellular Oncology |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2018 |
Keywords
- cell cycle entry
- cellular quiescence
- quiescence depth
- Rb-E2F pathway
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
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Cite this
Fujimaki, K., & Yao, G. (2018). Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy. Molecular and Cellular Oncology, 5(1), [e1403531]. https://doi.org/10.1080/23723556.2017.1403531