Abstract
The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
Original language | English (US) |
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Article number | e1403531 |
Journal | Molecular and Cellular Oncology |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 2018 |
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Keywords
- cell cycle entry
- cellular quiescence
- quiescence depth
- Rb-E2F pathway
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
Cite this
Crack the state of silence : Tune the depth of cellular quiescence for cancer therapy. / Fujimaki, Kotaro; Yao, Guang.
In: Molecular and Cellular Oncology, Vol. 5, No. 1, e1403531, 02.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Crack the state of silence
T2 - Tune the depth of cellular quiescence for cancer therapy
AU - Fujimaki, Kotaro
AU - Yao, Guang
PY - 2018/1/2
Y1 - 2018/1/2
N2 - The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
AB - The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
KW - cell cycle entry
KW - cellular quiescence
KW - quiescence depth
KW - Rb-E2F pathway
UR - http://www.scopus.com/inward/record.url?scp=85050722819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050722819&partnerID=8YFLogxK
U2 - 10.1080/23723556.2017.1403531
DO - 10.1080/23723556.2017.1403531
M3 - Article
AN - SCOPUS:85050722819
VL - 5
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 1
M1 - e1403531
ER -