Creative approaches towards the synthesis of 2,5-dihydro- furans, thiophenes, and pyrroles. One method does not fit all!

Matthew Brichacek, Jon T Njardarson

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

A single method is never sufficient, which is why there is a great need for developing many diverse and creative approaches towards every chemical substrate class. This statement is supported by the contents of this perspective in addition to providing the reader with a helpful synthetic roadmap for selecting a suitable method for the building blocks being discussed. Detailed in this review are eight different synthetic approaches that provide access to valuable 2,5-dihydro- furan, thiophene and pyrrole building blocks. Each approach is briefly presented and its limits discussed. The strengths and weaknesses of each approach are further highlighted with a graphical table summary at the end. This summary clearly drives home the point that for every chemical substrate class we need many good methods in order to provide access to every member of each class.

Original languageEnglish (US)
Pages (from-to)1761-1770
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume7
Issue number9
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Furans
Thiophenes
Pyrroles
furans
pyrroles
thiophenes
Substrates
synthesis
readers
furan

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

@article{5c9d8f244ebf4078b50d82bd4af1322f,
title = "Creative approaches towards the synthesis of 2,5-dihydro- furans, thiophenes, and pyrroles. One method does not fit all!",
abstract = "A single method is never sufficient, which is why there is a great need for developing many diverse and creative approaches towards every chemical substrate class. This statement is supported by the contents of this perspective in addition to providing the reader with a helpful synthetic roadmap for selecting a suitable method for the building blocks being discussed. Detailed in this review are eight different synthetic approaches that provide access to valuable 2,5-dihydro- furan, thiophene and pyrrole building blocks. Each approach is briefly presented and its limits discussed. The strengths and weaknesses of each approach are further highlighted with a graphical table summary at the end. This summary clearly drives home the point that for every chemical substrate class we need many good methods in order to provide access to every member of each class.",
author = "Matthew Brichacek and Njardarson, {Jon T}",
year = "2009",
doi = "10.1039/b900236g",
language = "English (US)",
volume = "7",
pages = "1761--1770",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "9",

}

TY - JOUR

T1 - Creative approaches towards the synthesis of 2,5-dihydro- furans, thiophenes, and pyrroles. One method does not fit all!

AU - Brichacek, Matthew

AU - Njardarson, Jon T

PY - 2009

Y1 - 2009

N2 - A single method is never sufficient, which is why there is a great need for developing many diverse and creative approaches towards every chemical substrate class. This statement is supported by the contents of this perspective in addition to providing the reader with a helpful synthetic roadmap for selecting a suitable method for the building blocks being discussed. Detailed in this review are eight different synthetic approaches that provide access to valuable 2,5-dihydro- furan, thiophene and pyrrole building blocks. Each approach is briefly presented and its limits discussed. The strengths and weaknesses of each approach are further highlighted with a graphical table summary at the end. This summary clearly drives home the point that for every chemical substrate class we need many good methods in order to provide access to every member of each class.

AB - A single method is never sufficient, which is why there is a great need for developing many diverse and creative approaches towards every chemical substrate class. This statement is supported by the contents of this perspective in addition to providing the reader with a helpful synthetic roadmap for selecting a suitable method for the building blocks being discussed. Detailed in this review are eight different synthetic approaches that provide access to valuable 2,5-dihydro- furan, thiophene and pyrrole building blocks. Each approach is briefly presented and its limits discussed. The strengths and weaknesses of each approach are further highlighted with a graphical table summary at the end. This summary clearly drives home the point that for every chemical substrate class we need many good methods in order to provide access to every member of each class.

UR - http://www.scopus.com/inward/record.url?scp=64549096370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64549096370&partnerID=8YFLogxK

U2 - 10.1039/b900236g

DO - 10.1039/b900236g

M3 - Article

C2 - 19590767

AN - SCOPUS:64549096370

VL - 7

SP - 1761

EP - 1770

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 9

ER -