Critical review in oral biology and medicine: Sensitivity of salivary glands to radiation: From animal models to therapies

O. Grundmann, G. C. Mitchell, Kirsten Limesand

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

Original languageEnglish (US)
Pages (from-to)894-903
Number of pages10
JournalJournal of Dental Research
Volume88
Issue number10
DOIs
Publication statusPublished - Oct 2009

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Keywords

  • Animal models
  • Radiation
  • Salivary gland dysfunction
  • Salivary glands
  • Therapy
  • Xerostomia.

ASJC Scopus subject areas

  • Dentistry(all)

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