TY - JOUR
T1 - Criticism of FDA Recommendations for Theophylline Dosage
AU - Murphy, John E.
AU - Ward, Earl S.
PY - 1980/9/25
Y1 - 1980/9/25
N2 - To the Editor: After a good deal of prodding, 1 the FDA recently issued new guidelines2 for dosage in patients receiving theophylline. The widespread use of the maintenance dose, 0.9 mg per kilogram of body weight per hour, established in the classic article by Mitenko and Ogilvie, 3 has led to an unacceptable incidence of toxic reactions to theophylline and has necessitated the release of new recommendations. In an attempt to rectify the situation, the FDA has created unnecessary problems: it has provided two sets of maintenance doses, one for the first 12 hours after the loading dose and another for the.
AB - To the Editor: After a good deal of prodding, 1 the FDA recently issued new guidelines2 for dosage in patients receiving theophylline. The widespread use of the maintenance dose, 0.9 mg per kilogram of body weight per hour, established in the classic article by Mitenko and Ogilvie, 3 has led to an unacceptable incidence of toxic reactions to theophylline and has necessitated the release of new recommendations. In an attempt to rectify the situation, the FDA has created unnecessary problems: it has provided two sets of maintenance doses, one for the first 12 hours after the loading dose and another for the.
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U2 - 10.1056/NEJM198009253031320
DO - 10.1056/NEJM198009253031320
M3 - Letter
C2 - 7402287
AN - SCOPUS:0018820421
VL - 303
SP - 760
EP - 761
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 13
ER -