Cryptosporidium species and subtypes and clinical manifestations in children, Peru

Vitaliano A. Cama, Caryn Bern, Jacqueline Roberts, Lilia Cabrera, Charles R Sterling, Ynes Ortega, Robert H. Gilman, Lihua Xiao

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.

Original languageEnglish (US)
Pages (from-to)1567-1574
Number of pages8
JournalEmerging Infectious Diseases
Volume14
Issue number10
DOIs
StatePublished - Oct 2008

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Cryptosporidium
Peru
Diarrhea
Nausea
Vomiting
Genotype
Felis
Oocysts
Infection
Parturition

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Cryptosporidium species and subtypes and clinical manifestations in children, Peru. / Cama, Vitaliano A.; Bern, Caryn; Roberts, Jacqueline; Cabrera, Lilia; Sterling, Charles R; Ortega, Ynes; Gilman, Robert H.; Xiao, Lihua.

In: Emerging Infectious Diseases, Vol. 14, No. 10, 10.2008, p. 1567-1574.

Research output: Contribution to journalArticle

Cama, VA, Bern, C, Roberts, J, Cabrera, L, Sterling, CR, Ortega, Y, Gilman, RH & Xiao, L 2008, 'Cryptosporidium species and subtypes and clinical manifestations in children, Peru', Emerging Infectious Diseases, vol. 14, no. 10, pp. 1567-1574. https://doi.org/10.3201/eid1410.071273
Cama, Vitaliano A. ; Bern, Caryn ; Roberts, Jacqueline ; Cabrera, Lilia ; Sterling, Charles R ; Ortega, Ynes ; Gilman, Robert H. ; Xiao, Lihua. / Cryptosporidium species and subtypes and clinical manifestations in children, Peru. In: Emerging Infectious Diseases. 2008 ; Vol. 14, No. 10. pp. 1567-1574.
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