Crystal structure analysis of deamino-oxytocin

Conformational flexibility and receptor binding

S. P. Wood, I. J. Tickle, A. M. Treharne, J. E. Pitts, Y. Mascarenhas, J. Y. Li, J. Husain, S. Cooper, T. L. Blundell, Victor J Hruby, A. Buku, A. J. Fischman, H. R. Wyssbrod

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Two crystal structures of deamino-oxytocin have been determined at better than 1.1 Å resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalScience
Volume232
Issue number4750
StatePublished - 1986

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Oxytocin
Disulfides
X-Rays

ASJC Scopus subject areas

  • General

Cite this

Wood, S. P., Tickle, I. J., Treharne, A. M., Pitts, J. E., Mascarenhas, Y., Li, J. Y., ... Wyssbrod, H. R. (1986). Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding. Science, 232(4750), 633-636.

Crystal structure analysis of deamino-oxytocin : Conformational flexibility and receptor binding. / Wood, S. P.; Tickle, I. J.; Treharne, A. M.; Pitts, J. E.; Mascarenhas, Y.; Li, J. Y.; Husain, J.; Cooper, S.; Blundell, T. L.; Hruby, Victor J; Buku, A.; Fischman, A. J.; Wyssbrod, H. R.

In: Science, Vol. 232, No. 4750, 1986, p. 633-636.

Research output: Contribution to journalArticle

Wood, SP, Tickle, IJ, Treharne, AM, Pitts, JE, Mascarenhas, Y, Li, JY, Husain, J, Cooper, S, Blundell, TL, Hruby, VJ, Buku, A, Fischman, AJ & Wyssbrod, HR 1986, 'Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding', Science, vol. 232, no. 4750, pp. 633-636.
Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY et al. Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding. Science. 1986;232(4750):633-636.
Wood, S. P. ; Tickle, I. J. ; Treharne, A. M. ; Pitts, J. E. ; Mascarenhas, Y. ; Li, J. Y. ; Husain, J. ; Cooper, S. ; Blundell, T. L. ; Hruby, Victor J ; Buku, A. ; Fischman, A. J. ; Wyssbrod, H. R. / Crystal structure analysis of deamino-oxytocin : Conformational flexibility and receptor binding. In: Science. 1986 ; Vol. 232, No. 4750. pp. 633-636.
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