Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding

S. P. Wood, I. J. Tickle, A. M. Treharne, J. E. Pitts, Y. Mascarenhas, J. Y. Li, J. Husain, S. Cooper, T. L. Blundell, V. J. Hruby, A. Buku, A. J. Fischman, H. R. Wyssbrod

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Abstract

Two crystal structures of deamino-oxytocin have been determined at better than 1.1 Å resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalScience
Volume232
Issue number4750
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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    Wood, S. P., Tickle, I. J., Treharne, A. M., Pitts, J. E., Mascarenhas, Y., Li, J. Y., Husain, J., Cooper, S., Blundell, T. L., Hruby, V. J., Buku, A., Fischman, A. J., & Wyssbrod, H. R. (1986). Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding. Science, 232(4750), 633-636. https://doi.org/10.1126/science.3008332