CT and MRI early vessel signs reflect clot composition in acute stroke

David S. Liebeskind, Nerses Sanossian, William H. Yong, Sidney Starkman, Michael P. Tsang, Antonio L. Moya, David D. Zheng, Anna M. Abolian, Doojin Kim, Latisha K. Ali, Samir H. Shah, Amytis Towfighi, Bruce Ovbiagele, Stella Kidwell, Satoshi Tateshima, Reza Jahan, Gary R. Duckwiler, Fernando Viñuela, Noriko Salamon, J. Pablo VillablancaHarry V. Vinters, Victor J. Marder, Jeffrey L. Saver

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-The purpose of this study was to provide the first correlative study of the hyperdense middle cerebral artery sign (HMCAS) and gradient-echo MRI blooming artifact (BA) with pathology of retrieved thrombi in acute ischemic stroke. METHODS-Noncontrast CT and gradient-echo MRI studies before mechanical thrombectomy in 50 consecutive cases of acute middle cerebral artery ischemic stroke were reviewed blinded to clinical and pathology data. Occlusions retrieved by thrombectomy underwent histopathologic analysis, including automated quantitative and qualitative rating of proportion composed of red blood cells (RBCs), white blood cells, and fibrin on microscopy of sectioned thrombi. RESULTS-Among 50 patients, mean age was 66 years and 48% were female. Mean (SD) proportion was 61% (±21) fibrin, 34% (±21) RBCs, and 4% (±2) white blood cells. Of retrieved clots, 22 (44%) were fibrin-dominant, 13 (26%) RBC-dominant, and 15 (30%) mixed. HMCAS was identified in 10 of 20 middle cerebral artery stroke cases with CT with mean Hounsfield Unit density of 61 (±8 SD). BA occurred in 17 of 32 with gradient-echo MRI. HMCAS was more commonly seen with RBC-dominant and mixed than fibrin-dominant clots (100% versus 67% versus 20%, P=0.016). Mean percent RBC composition was higher in clots associated with HMCAS (47% versus 22%, P=0.016). BA was more common in RBC-dominant and mixed clots compared with fibrin-dominant clots (100% versus 63% versus 25%, P=0.002). Mean percent RBC was greater with BA (42% versus 23%, P=0.011). CONCLUSIONS-CT HMCAS and gradient-echo MRI BA reflect pathology of occlusive thrombus. RBC content determines appearance of HMCAS and BA, whereas absence of HMCAS or BA may indicate fibrin-predominant occlusive thrombi.

Original languageEnglish (US)
Pages (from-to)1237-1243
Number of pages7
JournalStroke
Volume42
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Middle Cerebral Artery
Artifacts
Erythrocytes
Fibrin
Stroke
Thrombosis
Thrombectomy
Middle Cerebral Artery Infarction
Leukocytes
Pathology
Clinical Pathology
Microscopy

Keywords

  • cerebral ischemia
  • CT
  • MRI
  • stroke
  • thrombus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Liebeskind, D. S., Sanossian, N., Yong, W. H., Starkman, S., Tsang, M. P., Moya, A. L., ... Saver, J. L. (2011). CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke, 42(5), 1237-1243. https://doi.org/10.1161/STROKEAHA.110.605576

CT and MRI early vessel signs reflect clot composition in acute stroke. / Liebeskind, David S.; Sanossian, Nerses; Yong, William H.; Starkman, Sidney; Tsang, Michael P.; Moya, Antonio L.; Zheng, David D.; Abolian, Anna M.; Kim, Doojin; Ali, Latisha K.; Shah, Samir H.; Towfighi, Amytis; Ovbiagele, Bruce; Kidwell, Stella; Tateshima, Satoshi; Jahan, Reza; Duckwiler, Gary R.; Viñuela, Fernando; Salamon, Noriko; Villablanca, J. Pablo; Vinters, Harry V.; Marder, Victor J.; Saver, Jeffrey L.

In: Stroke, Vol. 42, No. 5, 05.2011, p. 1237-1243.

Research output: Contribution to journalArticle

Liebeskind, DS, Sanossian, N, Yong, WH, Starkman, S, Tsang, MP, Moya, AL, Zheng, DD, Abolian, AM, Kim, D, Ali, LK, Shah, SH, Towfighi, A, Ovbiagele, B, Kidwell, S, Tateshima, S, Jahan, R, Duckwiler, GR, Viñuela, F, Salamon, N, Villablanca, JP, Vinters, HV, Marder, VJ & Saver, JL 2011, 'CT and MRI early vessel signs reflect clot composition in acute stroke', Stroke, vol. 42, no. 5, pp. 1237-1243. https://doi.org/10.1161/STROKEAHA.110.605576
Liebeskind DS, Sanossian N, Yong WH, Starkman S, Tsang MP, Moya AL et al. CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke. 2011 May;42(5):1237-1243. https://doi.org/10.1161/STROKEAHA.110.605576
Liebeskind, David S. ; Sanossian, Nerses ; Yong, William H. ; Starkman, Sidney ; Tsang, Michael P. ; Moya, Antonio L. ; Zheng, David D. ; Abolian, Anna M. ; Kim, Doojin ; Ali, Latisha K. ; Shah, Samir H. ; Towfighi, Amytis ; Ovbiagele, Bruce ; Kidwell, Stella ; Tateshima, Satoshi ; Jahan, Reza ; Duckwiler, Gary R. ; Viñuela, Fernando ; Salamon, Noriko ; Villablanca, J. Pablo ; Vinters, Harry V. ; Marder, Victor J. ; Saver, Jeffrey L. / CT and MRI early vessel signs reflect clot composition in acute stroke. In: Stroke. 2011 ; Vol. 42, No. 5. pp. 1237-1243.
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T1 - CT and MRI early vessel signs reflect clot composition in acute stroke

AU - Liebeskind, David S.

AU - Sanossian, Nerses

AU - Yong, William H.

AU - Starkman, Sidney

AU - Tsang, Michael P.

AU - Moya, Antonio L.

AU - Zheng, David D.

AU - Abolian, Anna M.

AU - Kim, Doojin

AU - Ali, Latisha K.

AU - Shah, Samir H.

AU - Towfighi, Amytis

AU - Ovbiagele, Bruce

AU - Kidwell, Stella

AU - Tateshima, Satoshi

AU - Jahan, Reza

AU - Duckwiler, Gary R.

AU - Viñuela, Fernando

AU - Salamon, Noriko

AU - Villablanca, J. Pablo

AU - Vinters, Harry V.

AU - Marder, Victor J.

AU - Saver, Jeffrey L.

PY - 2011/5

Y1 - 2011/5

N2 - BACKGROUND AND PURPOSE-The purpose of this study was to provide the first correlative study of the hyperdense middle cerebral artery sign (HMCAS) and gradient-echo MRI blooming artifact (BA) with pathology of retrieved thrombi in acute ischemic stroke. METHODS-Noncontrast CT and gradient-echo MRI studies before mechanical thrombectomy in 50 consecutive cases of acute middle cerebral artery ischemic stroke were reviewed blinded to clinical and pathology data. Occlusions retrieved by thrombectomy underwent histopathologic analysis, including automated quantitative and qualitative rating of proportion composed of red blood cells (RBCs), white blood cells, and fibrin on microscopy of sectioned thrombi. RESULTS-Among 50 patients, mean age was 66 years and 48% were female. Mean (SD) proportion was 61% (±21) fibrin, 34% (±21) RBCs, and 4% (±2) white blood cells. Of retrieved clots, 22 (44%) were fibrin-dominant, 13 (26%) RBC-dominant, and 15 (30%) mixed. HMCAS was identified in 10 of 20 middle cerebral artery stroke cases with CT with mean Hounsfield Unit density of 61 (±8 SD). BA occurred in 17 of 32 with gradient-echo MRI. HMCAS was more commonly seen with RBC-dominant and mixed than fibrin-dominant clots (100% versus 67% versus 20%, P=0.016). Mean percent RBC composition was higher in clots associated with HMCAS (47% versus 22%, P=0.016). BA was more common in RBC-dominant and mixed clots compared with fibrin-dominant clots (100% versus 63% versus 25%, P=0.002). Mean percent RBC was greater with BA (42% versus 23%, P=0.011). CONCLUSIONS-CT HMCAS and gradient-echo MRI BA reflect pathology of occlusive thrombus. RBC content determines appearance of HMCAS and BA, whereas absence of HMCAS or BA may indicate fibrin-predominant occlusive thrombi.

AB - BACKGROUND AND PURPOSE-The purpose of this study was to provide the first correlative study of the hyperdense middle cerebral artery sign (HMCAS) and gradient-echo MRI blooming artifact (BA) with pathology of retrieved thrombi in acute ischemic stroke. METHODS-Noncontrast CT and gradient-echo MRI studies before mechanical thrombectomy in 50 consecutive cases of acute middle cerebral artery ischemic stroke were reviewed blinded to clinical and pathology data. Occlusions retrieved by thrombectomy underwent histopathologic analysis, including automated quantitative and qualitative rating of proportion composed of red blood cells (RBCs), white blood cells, and fibrin on microscopy of sectioned thrombi. RESULTS-Among 50 patients, mean age was 66 years and 48% were female. Mean (SD) proportion was 61% (±21) fibrin, 34% (±21) RBCs, and 4% (±2) white blood cells. Of retrieved clots, 22 (44%) were fibrin-dominant, 13 (26%) RBC-dominant, and 15 (30%) mixed. HMCAS was identified in 10 of 20 middle cerebral artery stroke cases with CT with mean Hounsfield Unit density of 61 (±8 SD). BA occurred in 17 of 32 with gradient-echo MRI. HMCAS was more commonly seen with RBC-dominant and mixed than fibrin-dominant clots (100% versus 67% versus 20%, P=0.016). Mean percent RBC composition was higher in clots associated with HMCAS (47% versus 22%, P=0.016). BA was more common in RBC-dominant and mixed clots compared with fibrin-dominant clots (100% versus 63% versus 25%, P=0.002). Mean percent RBC was greater with BA (42% versus 23%, P=0.011). CONCLUSIONS-CT HMCAS and gradient-echo MRI BA reflect pathology of occlusive thrombus. RBC content determines appearance of HMCAS and BA, whereas absence of HMCAS or BA may indicate fibrin-predominant occlusive thrombi.

KW - cerebral ischemia

KW - CT

KW - MRI

KW - stroke

KW - thrombus

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