CTLA-4: New insights into its biological function and use in tumor immunotherapy

Jackson G. Egen, Michael S Kuhns, James P. Allison

Research output: Contribution to journalArticle

609 Citations (Scopus)

Abstract

The discovery of multiple costimulatory cell surface molecules that influence the course of T cell activation has increased our appreciation of the complexity of the T cell response. It remains clear, however, that CD28 and cytotoxic T lymphocyte antigen 4 (CTLA-4) are the critical costimulatory receptors that determine the early outcome of stimulation through the T cell antigen receptor (TCR). Details of how the T cell integrates TCR stimulation with the costimulatory signals of CD28 and the inhibitory signals of CTLA-4 remain to be established, but unique features of the cell biology of CTLA-4 provide important insights into its function. We summarize here recent findings that suggest a previously unrecognized role for CTLA-4 in the regulation of T cell responses. We also describe preclinical and clinical results that indicate manipulation of CTLA-4 has considerable promise as a strategy for the immunotherapy of cancer.

Original languageEnglish (US)
Pages (from-to)611-618
Number of pages8
JournalNature Immunology
Volume3
Issue number7
DOIs
StatePublished - 2002
Externally publishedYes

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CTLA-4 Antigen
Immunotherapy
T-Lymphocytes
Neoplasms
T-Cell Antigen Receptor
Cell Biology

ASJC Scopus subject areas

  • Immunology

Cite this

CTLA-4 : New insights into its biological function and use in tumor immunotherapy. / Egen, Jackson G.; Kuhns, Michael S; Allison, James P.

In: Nature Immunology, Vol. 3, No. 7, 2002, p. 611-618.

Research output: Contribution to journalArticle

Egen, Jackson G. ; Kuhns, Michael S ; Allison, James P. / CTLA-4 : New insights into its biological function and use in tumor immunotherapy. In: Nature Immunology. 2002 ; Vol. 3, No. 7. pp. 611-618.
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