CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

Joseph J. Kieber, Madge Rothenberg, Gregg Roman, Kenneth A Feldmann, Joseph R. Ecker

Research output: Contribution to journalArticle

1317 Citations (Scopus)

Abstract

We isolated a recessive Arabidopsis mutant, ctr1, that constitutively exhibits seedling and adult phenotypes observed in plants treated with the plant hormone ethylene. The ctr1 adult morphology can be phenocopied by treatment of wild-type plants with exogenous ethylene and is due, at least in part, to inhibition of cell elongation. Seedlings and adult ctr1 plants show constitutive expression of ethylene-regulated genes. The epistasis of ctr1 and other ethylene response mutants has defined the position of CTR1 in the ethylene signal transduction pathway. The CTR1 gene has been cloned, and the DNA sequences of four mutant alleles were determined. The gene encodes a putative serine/threonine protein kinase that is most closely related to the Raf protein kinase family.

Original languageEnglish (US)
Pages (from-to)427-441
Number of pages15
JournalCell
Volume72
Issue number3
DOIs
StatePublished - Feb 12 1993

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Arabidopsis
Protein Kinases
Genes
Seedlings
raf Kinases
Signal transduction
Plant Growth Regulators
Protein-Serine-Threonine Kinases
DNA sequences
Elongation
Signal Transduction
Alleles
Cells
ethylene
Phenotype

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases. / Kieber, Joseph J.; Rothenberg, Madge; Roman, Gregg; Feldmann, Kenneth A; Ecker, Joseph R.

In: Cell, Vol. 72, No. 3, 12.02.1993, p. 427-441.

Research output: Contribution to journalArticle

Kieber, Joseph J. ; Rothenberg, Madge ; Roman, Gregg ; Feldmann, Kenneth A ; Ecker, Joseph R. / CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases. In: Cell. 1993 ; Vol. 72, No. 3. pp. 427-441.
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