Cu-free click cycloaddition reactions in chemical biology

John C Jewett, Carolyn R. Bertozzi

Research output: Contribution to journalArticle

933 Citations (Scopus)

Abstract

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems - in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

Original languageEnglish (US)
Pages (from-to)1272-1279
Number of pages8
JournalChemical Society Reviews
Volume39
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

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Covalent bonds
Cycloaddition
Biological systems
Biocompatibility
Copper
Chemical reactions
Innovation

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Cu-free click cycloaddition reactions in chemical biology. / Jewett, John C; Bertozzi, Carolyn R.

In: Chemical Society Reviews, Vol. 39, No. 4, 2010, p. 1272-1279.

Research output: Contribution to journalArticle

Jewett, John C ; Bertozzi, Carolyn R. / Cu-free click cycloaddition reactions in chemical biology. In: Chemical Society Reviews. 2010 ; Vol. 39, No. 4. pp. 1272-1279.
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