Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States

Meghan B. Skiba, Paula B. Luis, Chelsea Alfafara, David D Billheimer, Claus Schneider, Janet L Funk

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Scope: Turmeric is a top selling dietary supplement (DS) in the United States with rapidly expanding usage. Therefore, turmeric DS formulations available for sale in an urban US retail marketplace are analyzed, and point of sale information is related to measures of quality relevant to safety. Methods and results: Eighty-seven unique turmeric DS are identified; a majority (94%) contained turmeric-derived curcuminoid extracts (TD-CE), which are combined with other bioactives in 47% of products, including piperine (24%), an additive that could alter the metabolism of concurrent medications. While curcuminoid content is within 80% of anticipated for a majority of products analyzed (n = 35), curcuminoid composition (% curcumin) did not meet US Pharmacopeia (USP) criteria for TD-CE in 59% and is suggestive of possible unlabeled use of synthetic curcumin in some. Lead content is associated with the inclusion of turmeric root and exceeded USP limits in one product. Residues of toxic class 1 or 2 solvents, which are not needed for TD-CE isolation, are present in 71% of products, although quantified levels were within USP-specified limits. Conclusion: Assessment of turmeric DS quality at point of sale is difficult for consumers and may best be managed in partnership with knowledgeable healthcare professionals.

Original languageEnglish (US)
Article number1800143
JournalMolecular Nutrition and Food Research
Volume62
Issue number14
DOIs
StatePublished - Jul 1 2018

Fingerprint

Curcuma
turmeric
Dietary Supplements
dietary supplements
markets
Safety
Pharmacopoeias
sales
Curcumin
curcumin
piperine
extracts
Formulated Food
Poisons
health care workers
drug therapy
Delivery of Health Care
metabolism

Keywords

  • curcumin
  • curcuminoids
  • dietary supplements
  • lead
  • solvents
  • turmeric

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Cite this

Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States. / Skiba, Meghan B.; Luis, Paula B.; Alfafara, Chelsea; Billheimer, David D; Schneider, Claus; Funk, Janet L.

In: Molecular Nutrition and Food Research, Vol. 62, No. 14, 1800143, 01.07.2018.

Research output: Contribution to journalArticle

@article{e1b36b0fdb2142f882b5a5677de4a798,
title = "Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States",
abstract = "Scope: Turmeric is a top selling dietary supplement (DS) in the United States with rapidly expanding usage. Therefore, turmeric DS formulations available for sale in an urban US retail marketplace are analyzed, and point of sale information is related to measures of quality relevant to safety. Methods and results: Eighty-seven unique turmeric DS are identified; a majority (94{\%}) contained turmeric-derived curcuminoid extracts (TD-CE), which are combined with other bioactives in 47{\%} of products, including piperine (24{\%}), an additive that could alter the metabolism of concurrent medications. While curcuminoid content is within 80{\%} of anticipated for a majority of products analyzed (n = 35), curcuminoid composition ({\%} curcumin) did not meet US Pharmacopeia (USP) criteria for TD-CE in 59{\%} and is suggestive of possible unlabeled use of synthetic curcumin in some. Lead content is associated with the inclusion of turmeric root and exceeded USP limits in one product. Residues of toxic class 1 or 2 solvents, which are not needed for TD-CE isolation, are present in 71{\%} of products, although quantified levels were within USP-specified limits. Conclusion: Assessment of turmeric DS quality at point of sale is difficult for consumers and may best be managed in partnership with knowledgeable healthcare professionals.",
keywords = "curcumin, curcuminoids, dietary supplements, lead, solvents, turmeric",
author = "Skiba, {Meghan B.} and Luis, {Paula B.} and Chelsea Alfafara and Billheimer, {David D} and Claus Schneider and Funk, {Janet L}",
year = "2018",
month = "7",
day = "1",
doi = "10.1002/mnfr.201800143",
language = "English (US)",
volume = "62",
journal = "Molecular Nutrition and Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH Verlag",
number = "14",

}

TY - JOUR

T1 - Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States

AU - Skiba, Meghan B.

AU - Luis, Paula B.

AU - Alfafara, Chelsea

AU - Billheimer, David D

AU - Schneider, Claus

AU - Funk, Janet L

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Scope: Turmeric is a top selling dietary supplement (DS) in the United States with rapidly expanding usage. Therefore, turmeric DS formulations available for sale in an urban US retail marketplace are analyzed, and point of sale information is related to measures of quality relevant to safety. Methods and results: Eighty-seven unique turmeric DS are identified; a majority (94%) contained turmeric-derived curcuminoid extracts (TD-CE), which are combined with other bioactives in 47% of products, including piperine (24%), an additive that could alter the metabolism of concurrent medications. While curcuminoid content is within 80% of anticipated for a majority of products analyzed (n = 35), curcuminoid composition (% curcumin) did not meet US Pharmacopeia (USP) criteria for TD-CE in 59% and is suggestive of possible unlabeled use of synthetic curcumin in some. Lead content is associated with the inclusion of turmeric root and exceeded USP limits in one product. Residues of toxic class 1 or 2 solvents, which are not needed for TD-CE isolation, are present in 71% of products, although quantified levels were within USP-specified limits. Conclusion: Assessment of turmeric DS quality at point of sale is difficult for consumers and may best be managed in partnership with knowledgeable healthcare professionals.

AB - Scope: Turmeric is a top selling dietary supplement (DS) in the United States with rapidly expanding usage. Therefore, turmeric DS formulations available for sale in an urban US retail marketplace are analyzed, and point of sale information is related to measures of quality relevant to safety. Methods and results: Eighty-seven unique turmeric DS are identified; a majority (94%) contained turmeric-derived curcuminoid extracts (TD-CE), which are combined with other bioactives in 47% of products, including piperine (24%), an additive that could alter the metabolism of concurrent medications. While curcuminoid content is within 80% of anticipated for a majority of products analyzed (n = 35), curcuminoid composition (% curcumin) did not meet US Pharmacopeia (USP) criteria for TD-CE in 59% and is suggestive of possible unlabeled use of synthetic curcumin in some. Lead content is associated with the inclusion of turmeric root and exceeded USP limits in one product. Residues of toxic class 1 or 2 solvents, which are not needed for TD-CE isolation, are present in 71% of products, although quantified levels were within USP-specified limits. Conclusion: Assessment of turmeric DS quality at point of sale is difficult for consumers and may best be managed in partnership with knowledgeable healthcare professionals.

KW - curcumin

KW - curcuminoids

KW - dietary supplements

KW - lead

KW - solvents

KW - turmeric

UR - http://www.scopus.com/inward/record.url?scp=85050381741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050381741&partnerID=8YFLogxK

U2 - 10.1002/mnfr.201800143

DO - 10.1002/mnfr.201800143

M3 - Article

AN - SCOPUS:85050381741

VL - 62

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

SN - 1613-4125

IS - 14

M1 - 1800143

ER -