TY - JOUR
T1 - Current state of knowledge on salivary gland cancers
AU - Helen Lin, H.
AU - Limesand, Kirsten H.
AU - Ann, David K.
N1 - Funding Information:
This work was supported in part by National Institutes of Health grants R01DE10742, R21DE023298, and R01DE026304 (H.H.L. and D.K.A.); R01DE023534 (K.H.L. and D.K.A.); and P30CA033572 (supporting research carried out in core facilities).
Publisher Copyright:
© 2018 Begell House, Inc.
PY - 2018
Y1 - 2018
N2 - Salivary gland cancers (SGCs), categorized as head and neck cancers (HNCs), constitute about 6% of head and neck cancer diagnoses based on estimate by American Head and Neck Society. Salivary gland tumors originate from different glandular cell types and are thus morphologically diverse. These tumors arise from any of the three major and various minor salivary glands. The incidence of SGCs has slowly increased during the last four decades. The etiology of SGCs is mostly unknown; however, specific gene mutations are associated with certain types of salivary tumors. Treatment options include surgical resection, radiation therapy (RT), chemotherapy, and multimodality therapy. HNC patients treated with RT often develop xerostomia and salivary hypofunction due to damaged salivary glands. In this review, we discuss etiology of SGCs, present findings on the role of autophagy in salivary tumorigenesis, review adverse effects of radiation treatment, and examine remedies for restoration of salivary function.
AB - Salivary gland cancers (SGCs), categorized as head and neck cancers (HNCs), constitute about 6% of head and neck cancer diagnoses based on estimate by American Head and Neck Society. Salivary gland tumors originate from different glandular cell types and are thus morphologically diverse. These tumors arise from any of the three major and various minor salivary glands. The incidence of SGCs has slowly increased during the last four decades. The etiology of SGCs is mostly unknown; however, specific gene mutations are associated with certain types of salivary tumors. Treatment options include surgical resection, radiation therapy (RT), chemotherapy, and multimodality therapy. HNC patients treated with RT often develop xerostomia and salivary hypofunction due to damaged salivary glands. In this review, we discuss etiology of SGCs, present findings on the role of autophagy in salivary tumorigenesis, review adverse effects of radiation treatment, and examine remedies for restoration of salivary function.
KW - Autophagy
KW - Radiation therapy
KW - Salivary gland cancer
KW - Xerostomia
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U2 - 10.1615/CritRevOncog.2018027598
DO - 10.1615/CritRevOncog.2018027598
M3 - Article
C2 - 30311570
AN - SCOPUS:85054775086
VL - 23
SP - 139
EP - 151
JO - Critical Reviews in Oncogenesis
JF - Critical Reviews in Oncogenesis
SN - 0893-9675
IS - 3-4
ER -