Current status of targeted microbubbles in diagnostic molecular imaging of pancreatic cancer

Natacha Jugniot, Rakesh Bam, Emmanuelle Meuillet, Evan C. Unger, Ramasamy Paulmurugan

Research output: Contribution to journalReview articlepeer-review

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is often associated with a poor prognosis due to silent onset, resistance to therapies, and rapid spreading. Most patients are ineligible for curable surgery as they present with advanced disease at the time of diagnosis. Present diagnostic methods relying on anatomical changes have various limitations including difficulty to discriminate between benign and malignant conditions, invasiveness, the ambiguity of imaging results, or the inability to detect molecular biomarkers of PDAC initiation and progression. Therefore, new imaging technologies with high sensitivity and specificity are critically needed for accurately detecting PDAC and noninvasively characterizing molecular features driving its pathogenesis. Contrast enhanced targeted ultrasound (CETUS) is an upcoming molecular imaging modality that specifically addresses these issues. Unlike anatomical imaging modalities such as CT and MRI, molecular imaging using CETUS is promising for early and accurate detection of PDAC. The use of molecularly targeted microbubbles that bind to neovascular targets can enhance the ultrasound signal specifically from malignant PDAC tissues. This review discusses the current state of diagnostic imaging modalities for pancreatic cancer and places a special focus on ultrasound targeted-microbubble technology together with its clinical translatability for PDAC detection.

Original languageEnglish (US)
Article numbere10183
JournalBioengineering and Translational Medicine
Volume6
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • cancer early detection
  • clinical translation
  • microbubbles
  • molecular imaging
  • pancreatic ductal adenocarcinoma
  • targeted-imaging agents
  • ultrasound

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Current status of targeted microbubbles in diagnostic molecular imaging of pancreatic cancer'. Together they form a unique fingerprint.

Cite this