Current Status of the PulseRider in the Treatment of Bifurcation Aneurysms: A Systematic Review

Pedro Aguilar-Salinas, Leonardo B.C. Brasiliense, Christina M. Walter, Ricardo A. Hanel, Travis M Dumont

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Background: The PulseRider is an innovative stent-like device designed for the treatment of intracranial bifurcation aneurysms. The aim of this study was to assess the current evidence on safety and effectiveness of the PulseRider. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The following databases were searched: PubMed, Ovid MEDLINE, and Scopus. The search strategy consisted of “pulserider,” “bifurcation aneurysm,” and “endovascular” in both AND and OR combinations. Studies included were original research articles in peer-reviewed journals. The manuscripts were thoroughly examined for study design, outcomes, and results. Results: Three studies were identified describing use of the PulseRider device in the treatment of 63 patients with 63 bifurcation aneurysms. We identified 2 multicenter case series and 1 single-arm clinical trial. The majority of aneurysms treated were located at the basilar tip (37, 58.7%). All devices were successfully deployed, and there were 5 intraoperative complications (7.9%), including 2 intraoperative aneurysm ruptures, 1 vessel dissection, and 2 thrombus formations. Immediate complete aneurysm occlusion was achieved in 61.9% (39/63) of cases and at the 6-month imaging follow-up, 66.7% (42/63) achieved complete aneurysm occlusion. One recanalization was reported in 1 of the multicenter case series within the 6-month follow-up. Conclusions: The PulseRider is safe and probably effective for the treatment of intracranial bifurcation aneurysms, sometimes not amenable for stent-assisted coiling. However, current evidence is limited to a small sample and short follow-up. In addition, the device has not been compared with other treatment modalities.

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalWorld Neurosurgery
Volume115
DOIs
StatePublished - Jul 1 2018

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Aneurysm
Equipment and Supplies
Intracranial Aneurysm
Stents
Therapeutics
Manuscripts
Intraoperative Complications
PubMed
MEDLINE
Meta-Analysis
Dissection
Rupture
Thrombosis
Outcome Assessment (Health Care)
Clinical Trials
Databases
Guidelines
Safety
Research

Keywords

  • Device
  • Embolization
  • Intracranial aneurysm
  • Pulserider

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Current Status of the PulseRider in the Treatment of Bifurcation Aneurysms : A Systematic Review. / Aguilar-Salinas, Pedro; Brasiliense, Leonardo B.C.; Walter, Christina M.; Hanel, Ricardo A.; Dumont, Travis M.

In: World Neurosurgery, Vol. 115, 01.07.2018, p. 288-294.

Research output: Contribution to journalReview article

Aguilar-Salinas, Pedro ; Brasiliense, Leonardo B.C. ; Walter, Christina M. ; Hanel, Ricardo A. ; Dumont, Travis M. / Current Status of the PulseRider in the Treatment of Bifurcation Aneurysms : A Systematic Review. In: World Neurosurgery. 2018 ; Vol. 115. pp. 288-294.
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title = "Current Status of the PulseRider in the Treatment of Bifurcation Aneurysms: A Systematic Review",
abstract = "Background: The PulseRider is an innovative stent-like device designed for the treatment of intracranial bifurcation aneurysms. The aim of this study was to assess the current evidence on safety and effectiveness of the PulseRider. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The following databases were searched: PubMed, Ovid MEDLINE, and Scopus. The search strategy consisted of “pulserider,” “bifurcation aneurysm,” and “endovascular” in both AND and OR combinations. Studies included were original research articles in peer-reviewed journals. The manuscripts were thoroughly examined for study design, outcomes, and results. Results: Three studies were identified describing use of the PulseRider device in the treatment of 63 patients with 63 bifurcation aneurysms. We identified 2 multicenter case series and 1 single-arm clinical trial. The majority of aneurysms treated were located at the basilar tip (37, 58.7{\%}). All devices were successfully deployed, and there were 5 intraoperative complications (7.9{\%}), including 2 intraoperative aneurysm ruptures, 1 vessel dissection, and 2 thrombus formations. Immediate complete aneurysm occlusion was achieved in 61.9{\%} (39/63) of cases and at the 6-month imaging follow-up, 66.7{\%} (42/63) achieved complete aneurysm occlusion. One recanalization was reported in 1 of the multicenter case series within the 6-month follow-up. Conclusions: The PulseRider is safe and probably effective for the treatment of intracranial bifurcation aneurysms, sometimes not amenable for stent-assisted coiling. However, current evidence is limited to a small sample and short follow-up. In addition, the device has not been compared with other treatment modalities.",
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