Cutaneous malignant melanoma (Arizona Cancer Center experience): I. Natural history and prognostic factors influencing survival in patients with stage I disease

F. L. Meyskens, D. H. Berdeaux, B. Parks, T. Tong, Lois J Loescher, T. E. Moon

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Abstract

The authors have studied the natural history of 377 patients with Stage I cutaneous malignant melanoma followed at the Arizona Cancer Center, Tucson. Two hundred eight patients, or 55%, remained free of metastatic disease after a median follow-up of 30 months. The survival at 5, 8, and 10 years was 69, 65, and 63%, respectively. Natural breakpoints in Breslow thickness for survival occurred in 0.85, 1.95, and 4.00 mm. These are not significantly different from those found by other investigators. A step-down multivariate analysis using the Cox regression model yielded four factors as highly significant in predicting survival: Breslow thickness (P < 0.001), an age/sex interaction (P = 0.0012), clinical ulceration (P = 0.0039), and a prophylactic node dissection (P = 0.019). No predictive value for a BANS or non-BANS location was detected. These results are discussed in reference to other large series which describe the natural history of cutaneous melanoma.

Original languageEnglish (US)
Pages (from-to)1207-1214
Number of pages8
JournalCancer
Volume62
Issue number6
StatePublished - 1988

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Natural History
Survival
Neoplasms
Proportional Hazards Models
Dissection
Melanoma
Multivariate Analysis
Research Personnel
Skin
Cutaneous Malignant Melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cutaneous malignant melanoma (Arizona Cancer Center experience) : I. Natural history and prognostic factors influencing survival in patients with stage I disease. / Meyskens, F. L.; Berdeaux, D. H.; Parks, B.; Tong, T.; Loescher, Lois J; Moon, T. E.

In: Cancer, Vol. 62, No. 6, 1988, p. 1207-1214.

Research output: Contribution to journalArticle

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AU - Loescher, Lois J

AU - Moon, T. E.

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N2 - The authors have studied the natural history of 377 patients with Stage I cutaneous malignant melanoma followed at the Arizona Cancer Center, Tucson. Two hundred eight patients, or 55%, remained free of metastatic disease after a median follow-up of 30 months. The survival at 5, 8, and 10 years was 69, 65, and 63%, respectively. Natural breakpoints in Breslow thickness for survival occurred in 0.85, 1.95, and 4.00 mm. These are not significantly different from those found by other investigators. A step-down multivariate analysis using the Cox regression model yielded four factors as highly significant in predicting survival: Breslow thickness (P < 0.001), an age/sex interaction (P = 0.0012), clinical ulceration (P = 0.0039), and a prophylactic node dissection (P = 0.019). No predictive value for a BANS or non-BANS location was detected. These results are discussed in reference to other large series which describe the natural history of cutaneous melanoma.

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